Sleep down state-active ID2/Nkx2.1 interneurons in the neocortex
| Autor: | Tim J. Viney, György Buzsáki, Sara Mederos, Yuta Senzai, Robert Machold, Bernardo Rudy, Manuel Valero, Ipshita Zutshi, Benjamin Schuman |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Cell type Thyroid Nuclear Factor 1 Action Potentials Posterior parietal cortex Mice Transgenic Nitric Oxide Synthase Type I Optogenetics Non-rapid eye movement sleep Article Mice 03 medical and health sciences 0302 clinical medicine Interneurons Parietal Lobe Neural Pathways medicine Animals Inhibitor of Differentiation Protein 2 Neuron type Neocortex Chemistry Pyramidal Cells musculoskeletal neural and ocular physiology General Neuroscience Sleep in non-human animals 030104 developmental biology medicine.anatomical_structure nervous system GABAergic Sleep Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Nat Neurosci |
| ISSN: | 1546-1726 1097-6256 |
| DOI: | 10.1038/s41593-021-00797-6 |
| Popis: | Pyramidal cells and GABAergic interneurons fire together in balanced cortical networks. In contrast to this general rule, we describe a distinct neuron type in mice and rats whose spiking activity is anti-correlated with all principal cells and interneurons in all brain states but, most prevalently, during the down state of non-REM (NREM) sleep. We identify these down state-active (DSA) neurons as deep-layer neocortical neurogliaform cells that express ID2 and Nkx2.1 and are weakly immunoreactive to neuronal nitric oxide synthase. DSA neurons are weakly excited by deep-layer pyramidal cells and strongly inhibited by several other GABAergic cell types. Spiking of DSA neurons modified the sequential firing order of other neurons at down–up transitions. Optogenetic activation of ID2(+)Nkx2.1(+) interneurons in the posterior parietal cortex during NREM sleep, but not during waking, interfered with consolidation of cue discrimination memory. Despite their sparsity, DSA neurons perform critical physiological functions. |
| Databáze: | OpenAIRE |
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