A network pharmacology-based study on Alzheimer disease prevention and treatment of Qiong Yu Gao
| Autor: | Ren-kai Li, Fei Gao, Li-jie Huang, Jieshu You, Wei-ling Qu, Xia-lin Wu, Ming-yue Zhang, Wei Chen, Huan-lan Liu, Chen-yue Li |
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| Rok vydání: | 2020 |
| Předmět: |
Genetic testing
Molecular mechanisms of pharmacological action Gene regulatory network Acetylcholine receptor signaling pathway lcsh:Analysis Computational biology Biology lcsh:Computer applications to medicine. Medical informatics Biochemistry Gene regulatory networks 03 medical and health sciences Insulin Resistance Pathway 0302 clinical medicine Genetics medicine Molecular Biology Gene 030304 developmental biology 0303 health sciences Mechanism (biology) Research lcsh:QA299.6-433 Chinese traditional medicine.disease Actin cytoskeleton Computer Science Applications Computational Mathematics Computational Theory and Mathematics lcsh:R858-859.7 Medicine Alzheimer disease Signal transduction Alzheimer's disease 030217 neurology & neurosurgery |
| Zdroj: | BioData Mining BioData Mining, Vol 13, Iss 1, Pp 1-12 (2020) |
| ISSN: | 1756-0381 |
| DOI: | 10.1186/s13040-020-00212-z |
| Popis: | Background and objective As the pathological mechanisms of AD are complex, increasing evidence have demonstrated Chinese Medicine with multi-ingredients and multi-targets may be more suitable for the treatment of diseases with complex pathogenesis. Therefore, the study was to preliminarily decipher the bioactive compounds and potential mechanisms of Qiong Yu Gao (QYG) for AD prevention and treatment by an integrated network pharmacology approach. Methods Putative ingredients of QYG and significant genes of AD were retrieved from public database after screening. Then QYG ingredients target proteins/genes were obtained by target fishing. Compound-target-disease network was constructed using Cytoscape to decipher the mechanism of QYG for AD. KEGG pathway and GO enrichment analysis were performed to investigate the molecular mechanisms and pathways related to QYG for AD treatments. Results Finally, 70 compounds and 511 relative drug targets were collected. In which, 17 representative direct targets were found. Gene ontology enrichment analysis revealed that the adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway was the key biological processes and were regulated simultaneously by the 17 direct targets. The KEGG pathway enrichment analysis found that three signaling pathways were closely related to AD prevention and treatment by QYG, including PI3K-Akt signaling pathway, regulation of actin cytoskeleton pathway and insulin resistance pathway. Conclusion This study demonstrated that QYG exerted the effect of preventing and treating AD by regulating multi-targets with multi-components. Furthermore, the study demonstrated that a network pharmacology-based approach was useful for elucidation of the interrelationship between complex diseases and interventions of Chinese herbal medicines. |
| Databáze: | OpenAIRE |
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