Declining Hepatitis C Virus (HCV) Incidence in Dutch Human Immunodeficiency Virus-Positive Men Who Have Sex With Men After Unrestricted Access to HCV Therapy
| Autor: | Mark A. A. Claassen, Bart J. A. Rijnders, Stephanie Popping, Corine E Delsing, D. W. M. Verhagen, Anton S M Dofferhoff, Charles A. Boucher, Dirk Posthouwer, Marjo E. E. van Kasteren, Wouter F W Bierman, Arne van Eeden, Joop E. Arends, David A. M. C. van de Vijver, Robert Soetekouw, Paul H. P. Groeneveld, Edgar J G Peters, Kamilla D. Lettinga, Sebastiaan J. Hullegie, Eliane M. S. Leyten, Guido E.L. van den Berk, F. N. Lauw, Anne Boerekamps, Frank P. Kroon |
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| Přispěvatelé: | Internal medicine, Amsterdam Movement Sciences - Rehabilitation & Development, AII - Infectious diseases, Med Microbiol, Infect Dis & Infect Prev, MUMC+: DA MMI Staf (9), RS: FHML non-thematic output, Internal Medicine, Medical Microbiology & Infectious Diseases, Virology |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
NETHERLANDS Gonorrhea men having sex with men HIV Infections Rate ratio medicine.disease_cause Health Services Accessibility Men who have sex with men Sexual and Gender Minorities 0302 clinical medicine HIV Seropositivity Prospective Studies 030212 general & internal medicine acute Hepatitis C education.field_of_study Incidence (epidemiology) Incidence virus diseases Hepatitis C Middle Aged Infectious Diseases 030211 gastroenterology & hepatology Adult Microbiology (medical) medicine.medical_specialty TRANSMISSION Hepatitis C virus Population HIV-INFECTED MSM Antiviral Agents 03 medical and health sciences All institutes and research themes of the Radboud University Medical Center SDG 3 - Good Health and Well-being EPIDEMIC Internal medicine medicine Humans Homosexuality Male education REINFECTION INCIDENCE business.industry HIV Hepatitis C Chronic Models Theoretical medicine.disease lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] Immunology direct acting antiviral therapy Syphilis hepatitis C SEXUALLY-TRANSMITTED INFECTION business |
| Zdroj: | Boerekamps, A, van den Berk, G E, Lauw, F N, Leyten, E M, van Kasteren, M E, van Eeden, A, Posthouwer, D, Claassen, M A, Dofferhoff, A S, Verhagen, D W M, Bierman, W F, Lettinga, K D, Kroon, F P, Delsing, C E, Groeneveld, P H, Soetekouw, R, Peters, E J, Hullegie, S J, Popping, S, van de Vijver, D A M C, Boucher, C A, Arends, J E & Rijnders, B J 2018, ' Declining Hepatitis C Virus (HCV) Incidence in Dutch Human Immunodeficiency Virus-Positive Men Who Have Sex With Men After Unrestricted Access to HCV Therapy ', Clinical Infectious Diseases, vol. 66, no. 9, pp. 1360-1365 . https://doi.org/10.1093/cid/cix1007, https://doi.org/10.1093/cid/cix1007 Clinical Infectious Diseases, 66(9), 1360-1365 Clinical Infectious Diseases, 66(9), 1360-1365. Oxford University Press Clinical Infectious Diseases, 66, 1360-1365 Clinical Infectious Diseases, 66, 9, pp. 1360-1365 |
| ISSN: | 1058-4838 |
| DOI: | 10.1093/cid/cix1007 |
| Popis: | Background. Direct-acting antivirals (DAAa) cure hepatitis C virus (HCV) infections in 95% of infected patients. Modeling studies predict that universal HCV treatment will lead to a decrease in the incidence of new infections but real-life data are lacking. The incidence of HCV among Dutch human immunodeficiency virus (HIV)-positive men who have sex with men (MSM) has been high for >10 years. In 2015 DAAs became available to all Dutch HCV patients and resulted in a rapid treatment uptake in HIVpositive MSM. We assessed whether this uptake was followed by a decrease in the incidence of HCV infections.Methods. Two prospective studies of treatment for acute HCV infection enrolled patients in 17 Dutch HIV centers, having 76% of the total HIV-positive MSM population in care in the Netherlands. Patients were recruited in 2014 and 2016, the years before and after unrestricted DAA availability. We compared the HCV incidence in both years.Results. The incidence of acute HCV infection decreased from 93 infections during 8290 person-years of follow-up (PYFU) in 2014 (11.2/1000 PYFU; 95% confidence interval [CI], 9.1-13.7) to 49 during 8961 PYFU in 2016 (5.5/1000 PYFU; 4.1-7.2). The incidence rate ratio of 2016 compared with 2014 was 0.49 (95% CI,.35-.69). Simultaneously, a significant increase in the percentage positive syphilis (+2.2%) and gonorrhea (+2.8%) tests in HIV-positive MSM was observed at sexual health clinics across the Netherlands and contradicts a decrease in risk behavior as an alternative explanation.Conclusions. Unrestricted DAA availability in the Netherlands was followed by a 51% decrease in acute HCV infections among HIV-positive MSM. |
| Databáze: | OpenAIRE |
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