An analysis of the influence of sex hormones on Balb/c mice infected with Plasmodium berghei
| Autor: | Ana Maria Revorêdo da Silva Ventura, Letícia Nobre Lopes, Rosana Maria Feio Libonati, Felipe Augusto Folha Santos, Carina Guilhon Sequeira, Louize Caroline Marques Oliveira, Marialva Tereza Ferreira Araujo |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Male Camundongos Endog?micos BALB C Plasmodium berghei Parasitemia chemistry.chemical_compound Hemoglobins Mice Random Allocation Weight loss Testosterone Gonadal Steroid Hormones Mice Inbred BALB C biology Estradiol Estradiol cypionate Infectious Diseases Female medicine.symptom medicine.drug medicine.medical_specialty Anemia Ovariectomy Microbiology 03 medical and health sciences Mal?ria Internal medicine parasitic diseases medicine Parasitemia / parasitologia Modelos Animais de Doen?as Castra??o Animals Body Weight Horm?nios Esteroides Gonadais medicine.disease biology.organism_classification Taxa de Sobrevida Malaria 030104 developmental biology Castration Endocrinology chemistry Splenomegaly Weight gain Plasmodium berghei / efeitos de drogas Orchiectomy Spleen |
| Zdroj: | Repositório Digital do Instituto Evandro Chagas (Patuá) Instituto Evandro Chagas (IEC) instacron:IEC |
| ISSN: | 1096-1208 |
| Popis: | Financial support: IEC/SVS/MS; UEPA; CNPq (PIBIC). Universidade do Estado do Par?. Departamento de Cirurgia Experimental. Bel?m, PA, Brasil. Universidade Federal do Par?. N?cleo de Medicina Tropical. Bel?m, PA, Brasil. Universidade Federal do Par?. N?cleo de Medicina Tropical. Bel?m, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Universidade do Estado do Par?. Bel?m, PA, Brasil. Universidade Federal do Par?. N?cleo de Medicina Tropical. Bel?m, PA, Brasil. Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Laborat?rio de Ensaios Cl?nicos em Mal?ria. Ananindeua, PA, Brasil. Sex steroids can determine several responses in the clinical evolution of malaria. Seventy Balb-c mice were randomly distributed into 7 groups (10 mice per group): G1 to G6 corresponding to castrated females, castrated females that received estradiol cypionate, uncastrated females, castrated males, castrated males that received intramuscular testosterone decanoate and uncastrated males infected with Plasmodium berghei, and G7, the control group. The mice were evaluated with regard to survival, parasitemia, temperature, body weight, hemoglobin level (anemia) and splenic index. Castrated infected females had lower rates of survival. In the castrated male, the administration of testosterone had anegative influence on survival. There was a progressive increase in parasitemia without repercussions forsurvival. Castration had a significant influence on weight gain in females. Weight loss was observed in all mice, except those in groups G2 and G5, although this bore no direct relation to parasitemia. A significant and progressive decline in temperature and hemoglobin levels occurred in mice over the course of their infection, which differed from the G7 group. The weight of the spleen in relation to total body weight did not differ among the groups of infected mice, but was significantly higher than it was for the control group. |
| Databáze: | OpenAIRE |
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