Nucleation, reorganization and disassembly of an active network from lactose-modified chitosan mimicking biological matrices
| Autor: | Andrea Travan, Franco Furlani, Sergio Paoletti, Fioretta Asaro, Pasquale Sacco, Ivan Donati, Massimiliano Borgogna, Eleonora Marsich, Michela Cok, Francesca Scognamiglio |
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| Přispěvatelé: | Furlani, Franco, Sacco, Pasquale, Scognamiglio, Francesca, Asaro, Fioretta, Travan, Andrea, Borgogna, Massimiliano, Marsich, Eleonora, Cok, Michela, Paoletti, Sergio, Donati, Ivan |
| Rok vydání: | 2019 |
| Předmět: |
Polymers and Plastics
Active network Nucleation Chitosan derivative Biocompatible Materials Lactose Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Synthetic materials Chitosan chemistry.chemical_compound Strain-hardening Boric Acids Tissue engineering Materials Chemistry Boric acid Lactose-modified chitosan Non-linear rheology Organic Chemistry chemistry.chemical_classification Polymers and Plastic Polymer 021001 nanoscience & nanotechnology Dynamic Light Scattering 0104 chemical sciences chemistry Rheology 0210 nano-technology Active networking |
| Zdroj: | Carbohydrate Polymers. 208:451-456 |
| ISSN: | 0144-8617 |
| Popis: | Developing synthetic materials able to mimic micro- and macrorheological properties of natural networks opens up to novel applications and concepts in materials science. The present contribution describes an active network based on a semi-synthetic polymer, a lactitol-bearing chitosan derivative (Chitlac), and a transient inorganic cross-linker, boric acid. Due to the many and diverse anchoring points for boric acid on the flanking groups of Chitlac, the cross-links constantly break and reform in a highly dynamic fashion. The consequence is a network with unusual non-equilibrium and mechanical properties closely resembling the rheological behavior of natural three-dimensional arrangements and of cytoskeleton. Concepts like network nucleation, reorganization and disassembly are declined in terms of amount of the cross-linker, which acts as a putative motor for remodeling of the network upon application of energy. The out-of-equilibrium and non-linear behavior render the semi-synthetic system of great interest for tissue engineering and for developing in-vitro mimics of natural active matrices. |
| Databáze: | OpenAIRE |
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