Immunization Coverage and Antibody Retention against Rabies in Domestic Dogs in Lusaka District, Zambia
| Autor: | Herman M. Chambaro, Ryo Nakao, George Dautu, Bernard M. Hang’ombe, Masahiro Kajihara, Aaron S. Mweene, Hirofumi Sawa, Chikako Kataoka-Nakamura, Yongjin Qiu, Michihito Sasaki, Edgar Simulundu, Akina Mori-Kajihara, Chiho Kaneko, Norikazu Isoda, Ladslav Moonga, Chihiro Sugimoto, Naoto Ito, Hideaki Higashi, Joseph Ndebe, Ayato Takada, Walter Muleya, Ryosuke Omori |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Veterinary medicine Population Zambia rabies Disease cluster domestic dog antibody titer Article Herd immunity Immunology and Allergy Medicine education Molecular Biology education.field_of_study General Immunology and Microbiology biology business.industry immunization coverage Antibody titer medicine.disease Vaccination Infectious Diseases Immunization Africa biology.protein Rabies Antibody business |
| Zdroj: | Pathogens, Vol 10, Iss 738, p 738 (2021) Pathogens Volume 10 Issue 6 |
| ISSN: | 2076-0817 |
| Popis: | Rabies remains endemic in Zambia. Despite conducting canine vaccinations in Lusaka district, the vaccination coverage and actual seropositivity in the dog population in Lusaka district are rarely evaluated. This study estimated the seropositivity-based immunization coverage in the owned dog population in Lusaka district using the expanded program on immunization cluster survey method. The time-series trend of neutralizing antibodies against rabies in vaccinated dogs was also evaluated. Of 366 dogs in 200 dog-owning households in Lusaka district, blood samples were collected successfully from 251 dogs. In the sampled dogs, 42.2% (106/251) had an antibody titer ≥0.5 IU/mL. When the 115 dogs whose blood was not collected were assumed to be seronegative, the minimum immunization coverage in Lusaka district’s owned dog population was estimated at 29.0% (95% confidence interval: 22.4–35.5). It was also found that a single vaccination with certified vaccines is capable of inducing protective levels of antibodies. In contrast, higher antibody titers were observed in multiple-vaccinated dogs than in single-vaccinated dogs, coupled with the observation of a decline in antibody titer over time. These results suggest the importance of continuous booster immunization to maintain herd immunity and provide useful information to plan mass vaccination against rabies in Zambia. |
| Databáze: | OpenAIRE |
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