Prognostic value of extravascular lung water index in critically ill children with acute respiratory failure
| Autor: | Riccardo Lubrano, Giuliana Guido, Matteo Di Nardo, Nicola Pirozzi, Marco Elli, C Tomasello, Maria Antonietta Barbieri, E Pasotti, Elena Bellelli, Raffaele Masciangelo, Corrado Cecchetti |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Oxygenation index medicine.medical_treatment Critical Illness Cardiac index Mean airway pressure pulmonary edema children thermodilution index of oxygen exchange pulmonary permeability Critical Care and Intensive Care Medicine Anesthesiology medicine Humans Acute respiratory failure Child Survival rate Mechanical ventilation business.industry Infant respiratory system Pulmonary edema medicine.disease Prognosis respiratory tract diseases Survival Rate Anesthesia Child Preschool Acute Disease Extravascular Lung Water Female business Respiratory Insufficiency circulatory and respiratory physiology |
| Popis: | In critically ill adults, a reduction in the extravascular lung water index (EVLWi) decreases time on mechanical ventilation and improves survival. The purpose of this study is to assess the prognostic value of EVLWi in critically ill children with acute respiratory failure and investigate its relationships with PaO(2), PaO(2)/FiO(2) ratio, A-aDO(2), oxygenation index (OI), mean airway pressure, cardiac index, pulmonary permeability, and percent fluid overload.Twenty-seven children admitted to PICU with acute respiratory failure received volumetric hemodynamic and blood gas monitoring following initial stabilization and every 4 h thereafter, until discharge from PICU or death. All patients are grouped in two categories: nonsurvivors and survivors.Children with a fatal outcome had higher values of EVLWi on admission to PICU, as well as higher A-aDO(2) and OI, and lower PaO(2) and PaO(2)/FIO(2) ratio. After 24 h EVLWi decreased significantly only in survivors. As a survival indicator, EVLWi has good sensitivity and good specificity. Changes in EVLWi, OI, and mean airway pressure had a time-dependent influence on survival that proved significant according to the Cox test. Survivors spent fewer hours on mechanical ventilation. We detected a correlation of EVLWi with percent fluid overload and pulmonary permeability.Like OI and mean airway pressure, EVLWi on admission to PICU is predictive of survival and of time needed on mechanical ventilation. |
| Databáze: | OpenAIRE |
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