Urinary Prostate Cancer 3 Test: Toward the Age of Reason?
| Autor: | J. André, Virginie Vlaeminck-Guillem, Alain Ruffion, Philippe Paparel, Marian Devonec |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Nephrology PCA3 Oncology medicine.medical_specialty Pathology medicine.diagnostic_test business.industry Urology Urinary system Prostatic Neoplasms Reproducibility of Results Cancer medicine.disease Prostate cancer medicine.anatomical_structure Antigen Antigens Neoplasm Prostate Internal medicine Biopsy medicine Humans RNA business |
| Zdroj: | Urology. 75:447-453 |
| ISSN: | 0090-4295 |
| Popis: | The prostate cancer 3 (PCA3) gene was discovered in 1999, on the basis of differential expression between cancer and noncancerous prostate tissue. Including the first study published in 2003, 11 clinical studies have evaluated its utility for the diagnosis of prostate cancer by measuring the number of PCA3 RNA copies in urine enriched with prostate cells. Although the sensitivity of the PCA3 test was less than that of serum prostate-specific antigen (PSA), its specificity appeared to be much better, particularly in patients with a previous negative biopsy. Recent studies also have suggested that this test could be used to predict cancer prognosis. |
| Databáze: | OpenAIRE |
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