Higher frequency of abnormal serum angiopoietin-like protein 3 than abnormal cholesteryl ester transfer protein in Japanese hyperalphalipoproteinemic subjects
| Autor: | Takeaki Nagamine, Hyun Duk Moon, Katsuyuki Nakajima, Kunihiko Takanashi, Kiyoshi Kamiyama, Ikunosuke Sakurabayashi |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Apolipoprotein E
Endothelial lipase Male medicine.medical_specialty Hyperlipoproteinemias Adolescent Clinical Biochemistry Enzyme-Linked Immunosorbent Assay Biochemistry Young Adult Apolipoproteins E Japan Angiopoietin-like Protein Reference Values Internal medicine ANGPTL3 Cholesterylester transfer protein medicine Humans Normal range Triglycerides Aged Angiopoietin-Like Protein 3 Adiponectin biology Chemistry Biochemistry (medical) Cholesterol HDL General Medicine Japanese population Middle Aged Cholesterol Ester Transfer Proteins Endocrinology Angiopoietin-like Proteins Cholesterol Phenotype biology.protein lipids (amino acids peptides and proteins) Female Angiopoietins |
| Zdroj: | Clinica chimica acta; international journal of clinical chemistry. 398(1-2) |
| ISSN: | 0009-8981 |
| Popis: | Either a decrease of cholesteryl ester transfer protein (CETP) or an increase of angiopoietin-like protein 3 (ANGPTL3) in plasma has been shown to increase HDL-cholesterol (HDL-C) levels. However, as yet, it is not known which protein is more strongly associated with the modulation of HDL in the Japanese hyperalphalipoproteinemic (HALT) subjects.The serum concentration of ANGPTL3 and CETP, together with total cholesterol (TC), triglycerides (TG), adiponectin and ApoE phenotypes were determined in three groups with different HDL-C concentrations: low,40 mg/dl (n=51); normal, 40-90 mg/dl (n=126) and high,90 mg/dl (n=89) in the average Japanese population.The normal range (mean+/-2SD) of serum ANGPTL3 (218+/-144 ng/ml) and CETP (1.29+/-0.90 microg/ml) were determined in cases with 40-90 mg/dl HDL-C concentration. The frequency of abnormally high ANGPTL3 cases (362 ng/ml) were found to be significantly greater (44%) compared with those of low CETP cases (0.39 microg/ml, 4.5%) in HALT cases (90 mg/dl). ANGPTL3 showed a high correlation with HDL-C (r=0.67, P0.0001) and adiponectin (r=0.57, P0.0001), but not with CETP.In average Japanese population, abnormally higher frequency of increased ANGPTL3 prevail in HALT cases as compared with cases with low CETP. These findings suggest that ANGPTL3, the inhibitor of endothelial lipase, may be more strongly associated with increased HDL-C rather than CETP in plasma. Accordingly, ANGPTL3 seems to be a better target for the modulation of HDL-C. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect