Wogonin, a flavonoid isolated from Scutellaria baicalensis, has anti-viral activities against influenza infection via modulation of AMPK pathways
| Autor: | Rak Kyun Seong, Ok Sarah Shin, Ji Ae Kim |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Cell Survival
Viral Plaque Assay Pharmacology medicine.disease_cause Antiviral Agents Cell Line 03 medical and health sciences chemistry.chemical_compound Dogs 0302 clinical medicine Wogonin Interferon Virology Influenza A virus medicine Animals Humans Protein kinase A A549 cell Molecular Structure biology Chemistry Adenylate Kinase AMPK General Medicine biology.organism_classification Influenza B virus Infectious Diseases Viral replication 030220 oncology & carcinogenesis Flavanones Scutellaria baicalensis 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Acta virologica. 62:78-85 |
| ISSN: | 1336-2305 |
| DOI: | 10.4149/av_2018_109 |
| Popis: | Wogonin, a flavonoid isolated from Scutellaria baicalensis, has attracted increasing scientific attention in recent years because of its potent anti-tumor activity. Its role during viral infection has largely been unexplored. Wogonin treatment effectively suppressed both influenza A and B virus replication in Madin-Darby Canine Kidney (MDCK) cells and human lung epithelial (A549) cells. In contrast, wogonin treatment following influenza A virus infection led to up-regulation of interferon (IFN)-induced antiviral signaling. Additionally, influenza A virus infection in A549 cells induced 5' adenosine monophosphate-activated protein kinase (AMPK) phosphorylation and activation in a time-dependent manner and wogonin treatment led to the suppression of AMPK phosphorylation. Furthermore, the treatment with AMPK-specific inhibitor (compound C; CC) attenuated influenza A virus replication. These data suggest that wogonin possesses a potent anti-influenza activity mediated by regulation of AMPK activation, suggesting that wogonin has the potential to be developed as an anti-influenza drug. |
| Databáze: | OpenAIRE |
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