Increased postprandial glucagon-like peptide-1 (GLP-1) production after endoscopic gastrointestinal bypass using the Cousin lumen-apposing stent in a porcine model
| Autor: | Stephane Noel, Marc Barthet, François Cousin, Robert Caiazzo, Mehdi Daoudi, Julien Branche, Geoffroy Vanbiervliet, Gilles Solecki, François Pattou, Audrey Quenon, Violeta Raverdy, Thomas Hubert, François Henin, Valery Dalle |
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| Rok vydání: | 2017 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Malabsorption Endoscope Swine medicine.medical_treatment Self Expandable Metallic Stents Lumen (anatomy) Incretin Anastomosis Endoscopy Gastrointestinal 03 medical and health sciences 0302 clinical medicine Glucagon-Like Peptide 1 Animals Medicine Xylose business.industry Stomach Anastomosis Surgical Gastroenterology Stent Postprandial Period medicine.disease Surgery Jejunum Postprandial medicine.anatomical_structure Intestinal Absorption 030220 oncology & carcinogenesis Feasibility Studies Female 030211 gastroenterology & hepatology business |
| Zdroj: | Endoscopy. |
| ISSN: | 1438-8812 0013-726X |
| DOI: | 10.1055/s-0043-120439 |
| Popis: | Background and study aims Endoscopic techniques have demonstrated their effectiveness in metabolic surgery, notably through a gastrointestinal (GI) liner, with a less invasive approach than conventional surgery. Our study evaluates the safety and efficacy of endoscopic GI anastomosis (EGIA) using a lumen-apposing stent to secure the anastomosis. Materials and methods EGIA was performed using the transgastric approach with a two-channel endoscope with a novel stent (Cousin Biotech). First, a safety study with a follow-up of 12 months was performed on five piglets. Then, metabolic changes were investigated in a minipig model (n = 10) before and after EGIA or open GIA (OGIA). Results EGIA was technically successful with no complications observed during clinical monitoring. Endoscopic and postmortem examinations during the second part of study showed a secure anastomosis between the stomach and the intestinal limb in all except one minipig. Both minipigs subjected to EGIA and those in the control group (OGIA) exhibited increased postprandial glucagon-like peptide-1 (GLP-1) production (incretin secretion) and impaired D-xylose absorption (malabsorption effect). Conclusion Performing EGIA with this dedicated stent appears safe, technically feasible, durable, and reproducible in providing a simple and effective endoscopic GI bypass capable of ensuring metabolic effect. |
| Databáze: | OpenAIRE |
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