Eeg patterns in patients with prader–willi syndrome
| Autor: | Michele Sacco, Simona Filomena Madeo, Irene Rutigliano, Lorenzo Iughetti, Alessandra Li Pomi, Paolo Di Bella, Maurizio Delvecchio, G. Trifirò, Luigi Vetri, Maurizio Elia, Malgorzata Wasniewska, Silvana De Lucia |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pediatrics
medicine.medical_specialty Prader–Willi syndrome Neurosciences. Biological psychiatry. Neuropsychiatry Electroencephalography Short stature Article Epilepsy Neuroimaging wakefulness medicine EEG Genetics Prader–willi syndrome Sleep Wakefulness Ictal genetics Craniofacial sleep medicine.diagnostic_test business.industry General Neuroscience medicine.disease Hypotonia Endophenotype epilepsy medicine.symptom business RC321-571 |
| Zdroj: | Brain Sciences Brain Sciences, Vol 11, Iss 1045, p 1045 (2021) Volume 11 Issue 8 |
| Popis: | Prader–Willi syndrome (PWS) is a rare disease determined by the loss of the paternal copy of the 15q11-q13 region, and it is characterized by hypotonia, hyperphagia, obesity, short stature, hypogonadism, craniofacial dysmorphisms, and cognitive and behavioral disturbances. The aims of this retrospective study were to analyze interictal EEG findings in a group of PWS patients and to correlate them with genetic, clinical, and neuroimaging data. The demographic, clinical, genetic, EEG, and neuroimaging data of seventy-four patients were collected. Associations among the presence of paroxysmal EEG abnormalities, genotype, and clinical and neuroimaging features were investigated. Four patients (5.4%) presented drug-sensitive epilepsy. Interictal paroxysmal EEG abnormalities—focal or multifocal—were present in 25.7% of the cases, and the normalization of the EEG occurred in about 25% of the cases. In 63.2% of the cases, the paroxysmal abnormalities were bilaterally localized over the middle–posterior regions. Brain magnetic resonance imaging (MRI) was performed on 39 patients (abnormal in 59%). No relevant associations were found between paroxysmal EEG abnormalities and all of the other variables considered. Interictal paroxysmal EEG abnormalities—in particular, with a bilateral middle–posterior localization—could represent an important neurological feature of PWS that is not associated with genotype, cognitive or behavioral endophenotypes, MRI anomalies, or prognosis. |
| Databáze: | OpenAIRE |
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