Effects of amlodipine and candesartan on oxidized LDL level in patients with mild to moderate essential hypertension
| Autor: | Krista Fischer, Priit Kampus, Tiina Ristimäe, Kersti Zilmer, Mihkel Zilmer, Rein Teesalu, Piibe Muda |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Blood lipids Tetrazoles Blood Pressure Alkenes Essential hypertension law.invention Randomized controlled trial Double-Blind Method law Internal medicine Internal Medicine medicine Humans Amlodipine business.industry Biphenyl Compounds General Medicine Middle Aged medicine.disease Lipids Lipoproteins LDL Candesartan Blood pressure Endocrinology Hypertension lipids (amino acids peptides and proteins) Benzimidazoles Female Cardiology and Cardiovascular Medicine business Oxidized ldl Lipoprotein medicine.drug |
| Zdroj: | Blood pressure. 15(5) |
| ISSN: | 0803-7051 |
| Popis: | Objective. To compare the effects of amlodipine and candesartan on oxidized low-density lipoprotein (OxLDL), conjugated dienes (CD) and baseline diene conjugation in circulating low-density lipoproteins (LDL-BDC) level during antihypertensive treatment. Methods. Forty-nine patients with untreated mild to moderate essential hypertension were recruited in a randomized double-blind study to receive a daily dose either of 8 mg candesartan or 5 mg amlodipine for 16 weeks. Blood pressure, OxLDL, CD, LDL-BDC, triglycerides (TG), total cholesterol and lipoprotein cholesterol were measured at baseline, at week 2 and at week 16. Results. During treatment, in addition to a significant decrease in systolic and diastolic blood pressure, high level of OxLDL decreased significantly reaching practically upper kit reference values. Both treatment groups were similar with regard to the studied parameters at all time points. At the same time serum TG, lipoprotein and total cholesterol levels as well as LDL-BDC did not change and CD levels did not exceed endemic normal. Decrease in both systolic and diastolic blood pressure was associated with decrease in LDL-BDC/LDL. Conclusions. Besides their antihypertensive effects, both candesartan and amlodipine are efficient drugs for reducing OxLDL level, being neutral with regard to serum lipids. |
| Databáze: | OpenAIRE |
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