Combined treatment with growth hormone and gonadotropin-releasing hormone analogues in children with isolated growth hormone deficiency
| Autor: | Giuliana Andreani, Graziano Cesaretti, Carla Carlotti, Giuseppe Saggese |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Gonadotropin-releasing hormone Growth hormone Gonadotropin-Releasing Hormone Endocrinology Combined treatment Internal medicine Humans Medicine Child Chemotherapy business.industry Puberty Final height Bone age General Medicine Prognosis Body Height El Niño Isolated growth hormone deficiency Growth Hormone Drug Therapy Combination Female business Forecasting |
| Zdroj: | Acta Endocrinologica. 127:307-312 |
| ISSN: | 1479-683X 0804-4643 |
| Popis: | In subjects with an isolated GH deficiency the inhibition of puberty by GnRH-analogue administration may be attempted to delay the onset, or to prolong the duration, of pubertal maturation in order to improve final height. We report our experience on the matter in 10 subjects (6M, 4F) suffering from isolated GH deficiency with a chronological age ranging from 6.5 to 10.6 years at diagnosis. After a period of 1–5.1 years of GH treatment, GnRH-analogues (long-acting D-Trp-6-GnRH) were added to GH for 12 months, when six subjects were still prepubertal and four in early puberty. During combined therapy, a regression in pubertal development was shown in three out of four children in early puberty, while serum testosterone or estradiol decreased. Height velocity decreased (from 5.23±1.49 (mean±sd) to 4.12±0.67 cm/year; psd scores for bone age increased (from −0.75±0.42 to −0.47±0.55; p |
| Databáze: | OpenAIRE |
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