Histopathological, Immunohistochemical and Molecular Biologic Study of an Enucleated Specimen of a Case of Eales’ Disease
| Autor: | Gazal Patnaik, Anita Mahadevan, Jyotirmay Biswas, Radhika Mhatre, Amravi Shah, Dipankar Das, M K Janani, Sneha Giridhar |
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| Rok vydání: | 2021 |
| Předmět: |
Vasculitis
Pathology medicine.medical_specialty Tuberculosis genetic structures Enucleation Neovascularization Pathogenesis chemistry.chemical_compound Eales disease Retinal medicine Eales’ Retinal vasculitis business.industry Brief Report RE1-994 medicine.disease Immunohistochemistry eye diseases Ophthalmology Infectious Diseases PCR chemistry sense organs medicine.symptom business |
| Zdroj: | Journal of Ophthalmic Inflammation and Infection, Vol 11, Iss 1, Pp 1-4 (2021) Journal of Ophthalmic Inflammation and Infection |
| Popis: | Eales’ disease is a retinal vasculitis characterized by retinal inflammation, ischemia, and neovascularization. Exact pathogenesis of this disease is yet to be found out. We present a 29-year-old male, diagnosed with Eales’ disease in both eyes with persistent intraocular inflammation. Enucleation of the pthisical right eye was subjected for histopathological examination immunohistochemistry and molecular biologic study for mycobacterial tuberculosis DNA. Our study showed that Eales disease is probably a T cell mediated disease which is triggered by mycobacterial TB DNA. Further studies are needed to confirm our findings. |
| Databáze: | OpenAIRE |
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