Extra-Nodal, Nasal, Natural Killer T-Cell Lymphoma Treated With a Checkpoint Inhibitor: A Case Report of a Sustained Complete Response
| Autor: | Quoc Truong, Khalil Choucair, Radwan Diab, Syed Kamran, Bridget Adcock |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Oncology
Nasal cavity enktl medicine.medical_specialty abscopal effect medicine.medical_treatment immune checkpoint inhibitor Pembrolizumab Targeted therapy Internal medicine hemic and lymphatic diseases immune therapy Internal Medicine Medicine Stage (cooking) Receptor pd-1 inhibitor business.industry General Engineering Abscopal effect medicine.disease Natural killer T cell Lymphoma medicine.anatomical_structure business |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| Popis: | Extra-nodal natural killer T-cell lymphoma (ENKTL) is a rare and aggressive hematologic malignancy found in the nasal cavity and adjacent locations in 80% of cases, accounting for approximately 10% of non-Hodgkin lymphoma (NHL) and 0.4% of all cancers. Prognosis is typically poor and depends on stage, location, age, and tumor markers for targeted therapy, which is reserved for relapsed/refractory ENKTL. Of those, advanced clinical stage, higher Prognostic Index (PI), nodal involvement, Ki-67 expression, large cells, local tumor invasiveness, and circulating Epstein-Barr virus (EBV)-DNA levels are predictive of worse survival. Here, we present a rare case of a patient in remission 30 months after diagnosis of ENKTL following a sustained complete response to pembrolizumab, an immune checkpoint inhibitor targeting the programmed death-1 (PD-1) receptor. |
| Databáze: | OpenAIRE |
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