Efficacy of Fluvoxamine as a Treatment for Behavioral Symptoms in Frontotemporal Lobar Degeneration Patients
| Autor: | Ryuji Fukuhara, Kazue Shigenobu, Kenjiro Komori, Naruhiko Maki, Manabu Ikeda, Hirotaka Tanabe, Kazuhiko Hokoishi, Akihiko Nebu |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Cognitive Neuroscience Semantic dementia Fluvoxamine Neuropsychological Tests behavioral disciplines and activities Internal medicine mental disorders medicine Humans Overeating Psychiatry Aged Psychiatric Status Rating Scales Behavior Cognitive disorder nutritional and metabolic diseases Frontotemporal lobar degeneration Middle Aged Fluvoxamine Maleate medicine.disease Temporal Lobe Frontal Lobe nervous system diseases Psychiatry and Mental health Stereotypy (non-human) Treatment Outcome Nerve Degeneration Antidepressive Agents Second-Generation Female Geriatrics and Gerontology Psychology medicine.drug Frontotemporal dementia |
| Zdroj: | Dementia and Geriatric Cognitive Disorders. 17:117-121 |
| ISSN: | 1421-9824 1420-8008 |
| DOI: | 10.1159/000076343 |
| Popis: | Patients with frontotemporal lobar degeneration (FTLD) present a profound personality change, social misconduct, overeating, and stereotyped behavior. We examined the hypothesis that many of the behavioral symptoms of FTLD will respond to selective serotonin reuptake inhibitors (SSRIs). Sixteen FTLD patients were treated with an SSRI (fluvoxamine maleate) in an open 12-week trial. Treatment responses for stereotyped behavior and other neurobehavioral symptoms were evaluated by the Stereotypy Rating Inventory and the Neuropsychiatric Inventory. The behavioral symptoms, especially stereotyped behaviors of FTLD, significantly improved after treatment. Randomized, placebo- and other SSRI-controlled trials may improve available treatments. |
| Databáze: | OpenAIRE |
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