Strategies to optimize siRNA delivery to hepatocellular carcinoma cells
| Autor: | Gianluca Chiarappa, Francesca Perrone, Barbara Salis, Gabriele Grassi, Giancarlo Forte, Gabriele Pozzato, Concetta Russo Spena, Giuseppe Toffoli, Lucia De Stefano, Marica Garziera, Flavio Rizzolio, Francesco Musiani, Michela Abrami, Rossella Farra, Federica Tonon, Mario Grassi, Lucia Scarabel, Barbara Dapas |
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| Přispěvatelé: | Scarabel, Lucia, Perrone, Francesca, Garziera, Marica, Farra, Rossella, Grassi, Mario, Musiani, Francesco, RUSSO SPENA, Concetta, Salis, Barbara, DE STEFANO, Lucia, Toffoli, Giuseppe, Rizzolio, Flavio, Tonon, Federica, Abrami, Michela, Chiarappa, Gianluca, Pozzato, Gabriele, Forte, Giancarlo, Grassi, Gabriele, Dapas, Barbara, Russo Spena, Concetta, De Stefano, Lucia |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Small interfering RNA Carcinoma Hepatocellular drug delivery hepatocellular carcinoma liposome polymers siRNA polymer Pharmaceutical Science Antineoplastic Agents Settore BIO/11 - Biologia Molecolare Pharmacology Small Interfering Cell Line 03 medical and health sciences 0302 clinical medicine Gene expression medicine Animals Humans Liver Neoplasms RNA Small Interfering 3003 business.industry Carcinoma RNA Hepatocellular medicine.disease digestive system diseases 030104 developmental biology Late diagnosis 030220 oncology & carcinogenesis Hepatocellular carcinoma Drug delivery Cancer research Target gene Primary liver cancer business |
| Popis: | Introduction: hepatocellular carcinoma (hcc) is the predominant form of primary liver cancer and the second leading cause of cancer-associated mortality worldwide. available therapies for hcc have limited efficacy due to often late diagnosis and the general resistance of hcc to anti-cancer agents; therefore, the development of novel therapeutics is urgently required. small-interfering rna (sirna) molecules are short, double-stranded rnas that specifically recognize and bind the mrna of a target gene to inhibit gene expression. despite the great therapeutic potential of sirnas towards many human tumors including hcc, their use is limited by suboptimal delivery. Areas covered: In this review, we outline the current data regarding the therapeutic potential of siRNAs in HCC and describe the development of effective siRNA delivery systems. We detail the key problems associated with siRNA delivery and discuss the possible solutions. Finally, we provide examples of the various siRNA delivery strategies that have been employed in animal models of HCC and in human patients enrolled in clinical trials. Expert opinion: Despite the existing difficulties in siRNA delivery for HCC, the increasing scientific attention and breakthrough studies in this field is facilitating the design of novel and efficient technical solutions that may soon find practical applications |
| Databáze: | OpenAIRE |
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