Increased expression of ?-catenin predicts better prognosis in nonsmall cell lung carcinomas
| Autor: | Michio Shimizu, Keiji Furuuchi, Ichiro Kinoshita, Hirotoshi Dosaka-Akita, Tetsuya Moriuchi, Hiroyuki Katoh, Koichi Yamazaki, Shigeaki Ogura, Masaharu Nishimura, Fumihiro Hommura |
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| Rok vydání: | 2002 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Lung Neoplasms Cell Gene mutation Cyclin D1 Carcinoma Non-Small-Cell Lung medicine Humans beta Catenin Aged Neoplasm Staging biology Cell growth business.industry Wnt signaling pathway Cancer Middle Aged Prognosis medicine.disease Immunohistochemistry Gene Expression Regulation Neoplastic Cytoskeletal Proteins medicine.anatomical_structure Oncology Ki-67 Catenin Trans-Activators biology.protein Cancer research business |
| Zdroj: | Cancer. 94:752-758 |
| ISSN: | 1097-0142 0008-543X |
| Popis: | BACKGROUND β-Catenin has been shown to function as a Wnt signaling molecule to stimulate cyclin D1 expression and cell growth in several kinds of tumors. METHODS The authors immunohistochemically examined specimens of 217 surgically resected primary nonsmall cell lung carcinomas (NSCLCs) for β-catenin expression and classified them semiquantitatively into three categories, including those with high, moderate, and low scores of expression. RESULTS High, moderate, and low scores of expression were found in 37 (17.1%), 145 (66.8%), and 35 (16.1%) tumors, respectively. β-Catenin expression was not correlated with cyclin D1 expression, but was positively correlated with the Ki-67 cell growth fraction (P = 0.04). The direct sequencing analysis for the β-catenin gene mutation of 13 specimens of 217 tumors for the current study revealed no mutations. The relation between survival and β-catenin expression was evaluated in 148 potentially curatively resected tumors with pathologic Stages I–IIIA. A trend toward better survival was found in patients with tumors having higher scores. In multivariate analysis, high β-catenin expression was a significant and independent favorable prognostic factor (hazards ratio, 0.31; P = 0.007) as was pathologic stage. Analyzed by cell type, in nonsquamous cell carcinomas, patients with tumors having high scores survived a significantly longer time than those with tumors having moderate or low scores (5-year survival rates, 84%, 55%, and 32%, respectively; P = 0.02), and high β-catenin expression tended to be a favorable prognostic factor (hazards ratio, 0.32; P = 0.052). CONCLUSIONS These results indicate that, in NSCLCs, increased expression of β-catenin can predict favorable prognosis of patients with resected tumors, suggesting that accumulation of β-catenin has no or little oncogenic effect via activation of the Wnt pathway, unlike in colon carcinomas or hepatomas. Cancer 2002;94:752–8. © 2002 American Cancer Society. DOI 10.1002/cncr.10213 |
| Databáze: | OpenAIRE |
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