Early prediction of treatment outcome in acute myeloid leukemia by measurement of WT1 transcript levels in peripheral blood samples collected after chemotherapy
| Autor: | Emanuela Messa, Daniela Diverio, Enrico Gottardi, Miguel A. Sanz, Paolo Nicoli, Milena Fava, Daniela Cilloni, Francesca Messa, Sonia Carturan, Enrico Bracco, Giovanni Martinelli, Giuseppe Saglio, Francesca Arruga, Ilaria Defilippi, Renata Catalano, Francesco Lo-Coco |
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| Přispěvatelé: | Cilloni D, Messa F, Arruga F, Defilippi I, Gottardi E, Fava M, Carturan S, Catalano R, Bracco E, Messa E, Nicoli P, Diverio D, Sanz MA, Martinelli G, Lo-Coco F, Saglio G. |
| Rok vydání: | 2008 |
| Předmět: |
Oncology
Adult Risk medicine.medical_specialty Genes Wilms Tumor medicine.medical_treatment Antineoplastic Agents Polymerase Chain Reaction Recurrence Internal medicine medicine Humans Prospective cohort study WT1 Proteins Acute leukemia Chemotherapy Hematology business.industry Gene Expression Profiling Myeloid leukemia Induction chemotherapy Cancer Middle Aged medicine.disease Prognosis Minimal residual disease WT1 Neoplasm Proteins Gene Expression Regulation Neoplastic Leukemia Myeloid Acute Treatment Outcome Immunology ACUTE MYELOID LEUKEMIA business Settore MED/15 - Malattie del Sangue |
| Zdroj: | Haematologica. 93(6) |
| ISSN: | 1592-8721 |
| Popis: | The Wilms' tumor gene WT1 is a reliable marker for minimal residual disease assessment in acute leukemia patients. The study was designed to demonstrate the potential use of WT1 to establish quality of remission in acute leukemia patients for early identification of patients at high risk of relapse. A prospective study based on a quantitative Real-Time PCR (TaqMan) assay in 562 peripheral blood samples collected from 82 acute leukemia patients at diagnosis and during follow-up was established. The evaluation of WT1 in peripheral blood samples after induction chemotherapy can distinguish the continuous complete remission patients from those who obtain only an "apparent" complete remission and who could relapse within a few months. WT1 helps identify patients at high risk of relapse soon after induction chemotherapy allowing post-induction therapy in high risk patients to be intensified. |
| Databáze: | OpenAIRE |
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