Stable reprogramming of brain transcription profiles by the early social environment in a cooperatively breeding fish
| Autor: | Nadia Aubin-Horth, Barbara Taborsky, Linda Tschirren, Clémence Meunier |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Fish Proteins
Male 0106 biological sciences Receptors Steroid medicine.medical_specialty Corticotropin-Releasing Hormone Neolamprologus pulcher Molecular Sequence Data Stimulation Real-Time Polymerase Chain Reaction 010603 evolutionary biology 01 natural sciences General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Corticotropin-releasing hormone 0302 clinical medicine Glucocorticoid receptor Stress Physiological Cichlid Internal medicine biology.animal medicine Animals RNA Messenger Social Behavior Research Articles General Environmental Science Genetics Regulation of gene expression General Immunology and Microbiology biology 572: Biochemie Brain Vertebrate Cichlids Sequence Analysis DNA General Medicine biology.organism_classification Endocrinology Poikilotherm Gene Expression Regulation 570 Life sciences 590 Animals (Zoology) Female General Agricultural and Biological Sciences 030217 neurology & neurosurgery |
| Zdroj: | Proceedings. Biological sciences / The Royal Society |
| DOI: | 10.1098/rspb.2012.2605 |
| Popis: | Adult social behaviour can be persistently modified by early-life social experience. In rodents, such effects are induced by tactile maternal stimulation resulting in neuroendocrine modifications of the hypothalamic–pituitary–adrenal axis involved in stress responsiveness. Whether similar long-term alterations can occur in the hypothalamic–pituitary–interrenal (HPI) axis of poikilothermic vertebrates is unknown. We compared the expression of four genes of the HPI axis in adults of the cooperatively breeding cichlid Neolamprologus pulcher , which had been exposed to two early-life social treatments 1.5 years prior to brain sampling. Fish reared with parents and siblings had less brain expression of corticotropin-releasing factor and of the functional homologue of the mammalian glucocorticoid receptor (GR1) than individuals reared with same-age siblings only. Expression of the mineralocorticoid receptors (MR) did not differ between treatments, but the MR/GR1 expression ratio was markedly higher in fish reared with parents and siblings. Thus, we show here that early social experience can alter the programming of the stress axis in poikilothermic vertebrates, suggesting that this mechanism is deeply conserved within vertebrates. Moreover, we show for the first time that reprogramming of the stress axis of a vertebrate can be induced without tactile stimulation by parents. |
| Databáze: | OpenAIRE |
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