CHARACTERIZATION OF A BIOACTIVE DERIVATIVE OF CALOPHYLLOLIDE BY 2D NMR AND LC-MS/MS

Autor:	Kapil Vyas, R. Pichai, R. Mohan Kumar, L. Kalyanaraman, K. K. Sree Ganesh
Rok vydání:	2014
Předmět:	Calophyllolide Reaction mechanism Chromatography Clinical Biochemistry Pharmaceutical Science Carbon-13 NMR Biochemistry Analytical Chemistry Chiral column chromatography Sodium borohydride chemistry.chemical_compound chemistry Chirality (chemistry) Two-dimensional nuclear magnetic resonance spectroscopy Derivative (chemistry)
Zdroj:	Journal of Liquid Chromatography & Related Technologies. 37:1087-1093
ISSN:	1520-572X 1082-6076
Popis:	This study details the characterization of a novel and an unexpected cyclization reduction product of Calophyllolide (I), by using sodium borohydride. The structure of the derivative (II) was established as 6,10,11-tetramethyl-4-phenyl-6, 10-dihydro-2H-dipyrano [2, 3-f: 2′, 3′-h] chromen-2-one by 2D NMR experiments such as 1H-1H gCOSY, gHSQC, gHMBC, and LC-MS/MS along with 1H and 13C NMR spectra. A reversed-phase HPLC method and a chiral HPLC method were developed to evaluate the purity and chirality. A reaction mechanism for II was proposed. The synthesized compound was showing significant antimicrobial activity than the parent compound (I) when tested against various pathogenic bacteria and fungus.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b278b7d54d1a7e450f1506f75870c2e4 https://doi.org/10.1080/10826076.2013.765463 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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