Antibiotic-eluting hydrophilized PMMA bone cement with prolonged bactericidal effect for the treatment of osteomyelitis
| Autor: | Se Heang Oh, In Soo Lee, Eun Jo Oh, Oh Soo Kwon, Jin Ho Lee |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Staphylococcus aureus Materials science Compressive Strength medicine.drug_class Antibiotics Biomedical Engineering Dentistry 02 engineering and technology medicine.disease_cause Biomaterials Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Antiseptic Vancomycin Materials Testing medicine Animals Polymethyl Methacrylate Agar diffusion test 030222 orthopedics business.industry Osteomyelitis technology industry and agriculture Bone Cements Staphylococcal Infections equipment and supplies 021001 nanoscience & nanotechnology Bone cement medicine.disease Surgery Anti-Bacterial Agents Delayed-Action Preparations Orthopedic surgery 0210 nano-technology business medicine.drug |
| Zdroj: | Journal of biomaterials applications. 30(10) |
| ISSN: | 1530-8022 |
| Popis: | Osteomyelitis is still considered to be one of the major challenges for orthopedic surgeons despite advanced antiseptic surgical procedures and pharmaceutical therapeutics. In this study, hydrophilized poly(methyl methacrylate) (PMMA) bone cements containing Pluronic F68 (EG79PG28EG79) as a hydrophilic additive and vancomycin ( F68-VA cements) were prepared to allow the sustained release of the antibiotic for adequate periods of time without any significant loss of mechanical properties. The compressive strengths of the bone cements with Pluronic F68 compositions less than 7 wt% were not significantly different compared with the control vancomycin-loaded bone cement ( VA cement). The F68 (7 wt%)-VA cement showed sustained release of the antibiotic for up to 11 weeks and almost 100% release from the bone cement. It also prohibited the growth of S. aureus (zone of inhibition) over six weeks (the required period to treat osteomyelitis), and it did not show any notable cytotoxicity. From an animal study using a femoral osteomyelitis rat model, it was observed that the F68 (7 wt%)-VA cement was effective for the treatment of osteomyelitis, probably as a result of the prolonged release of antibiotic from the PMMA bone cement. On the basis of these findings, it can be suggested that the use of Pluronic F68 as a hydrophilic additive for antibiotic-eluting PMMA bone cement can be a promising strategy for the treatment of osteomyelitis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|