Avascular Necrosis of Bone: A Complication of Aggressive Therapy for Acute Lymphoblastic Leukemia
| Autor: | Sucheta Vaidya, Suresh K. Pai, Somjee Saika, Suresh H. Advani, Bhawna Sirohi |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Bone disease medicine.medical_treatment Avascular necrosis Femoral head Femur Head Necrosis Acute lymphocytic leukemia Antineoplastic Combined Chemotherapy Protocols medicine Humans Radiology Nuclear Medicine and imaging Radionuclide Imaging Bone pain Glucocorticoids Chemotherapy business.industry Combination chemotherapy Hematology General Medicine Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Surgery Radiography medicine.anatomical_structure Oncology Female medicine.symptom business Complication |
| Zdroj: | Acta Oncologica. 37:175-177 |
| ISSN: | 1651-226X 0284-186X |
| Popis: | The purpose of the present paper was to report cases of avascular necrosis of bone (AVNB) arising as a complication of chemotherapy for acute lymphoblastic leukemia (ALL). X-rays and 99mtechnicium-MDP bone scans were performed on patients with symptoms of bone pain, whereby five patients out of 850 patients were detected to have avascular necrosis of the femoral head. All had received aggressive chemotherapy with steroids. Two patients were still on therapy for the primary disease. In these patients further chemotherapy was continued without steroids. The median period from diagnosis of ALL to development of AVNB was 29 months. Three patients underwent corrective surgical procedures. To conclude, the data suggest that patients receiving combination chemotherapy, especially those with high cumulative doses, run a risk of developing AVNB. Awareness of this complication is important in order to have an early diagnosis so as to limit disability. |
| Databáze: | OpenAIRE |
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