Bioactivity-guided fractionation of the stem bark extract of Pterocarpus dalbergioides Roxb. ex Dc growing in Egypt
| Autor: | Moshera M. El-Sherei, Amani Sleem, Shaimaa A.A. Ahmed, Wafaa T. Islam, Camilia G. Michel |
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| Rok vydání: | 2013 |
| Předmět: |
Stem bark
Traditional medicine biology medicine.drug_class Butanol lcsh:RS1-441 Pterocarpus dalbergioides Fractionation biology.organism_classification Anti-inflammatory lcsh:Pharmacy and materia medica chemistry.chemical_compound chemistry visual_art Pterocarpus Genistin visual_art.visual_art_medium medicine Bark Antihyperglycemic |
| Zdroj: | Bulletin of Faculty of Pharmacy, Cairo University, Vol 51, Iss 1, Pp 1-5 (2013) |
| ISSN: | 1110-0931 |
| DOI: | 10.1016/j.bfopcu.2012.07.003 |
| Popis: | A bioactivity-guided investigation of the ethanolic extract (70%) of the stem bark of Pterocarpus dalbergioides Roxb. ex DC revealed that the butanol fraction possessed potent antihyperglycemic and anti-inflammatory activities at a dose of 100 mg/kg b.wt. compared to metformin (150 mg/kg b.wt.) and indomethacin (20 mg/kg b.wt.) respectively. Two phenolic acids viz: gentisic (1) and gallic (3) acids and isoflavone genistin (2) were isolated for the first time from the studied plant adopting a bioactivity-guided fractionation. Identification of the isolated compounds was achieved using physical, chemical and spectroscopic data. |
| Databáze: | OpenAIRE |
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