Enamel organ proteins as targets for antibodies in celiac disease: implications for oral health
| Autor: | Claudio Rodríguez-Camejo, Paula Arbildi, Alicia Marco, Verónica Beovide, Cecilia Sóñora, Ana Hernández |
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| Rok vydání: | 2015 |
| Předmět: |
Pathology
medicine.medical_specialty Swine Oral Health 03 medical and health sciences 0302 clinical medicine Dental Enamel Proteins stomatognathic system Ameloblasts Deciduous teeth Animals Humans Medicine Dental Enamel General Dentistry Amelogenin Enamel paint biology business.industry Enamel Organ Enamel organ nutritional and metabolic diseases 030206 dentistry Staining Celiac Disease stomatognathic diseases medicine.anatomical_structure visual_art Immunology visual_art.visual_art_medium biology.protein Immunohistochemistry Female 030211 gastroenterology & hepatology business Gliadin Ameloblast |
| Zdroj: | European Journal of Oral Sciences. 124:11-16 |
| ISSN: | 0909-8836 |
| DOI: | 10.1111/eos.12241 |
| Popis: | Enamel defects in permanent and deciduous teeth may be oral manifestations of celiac disease. Sometimes they are the only sign that points to this underdiagnosed autoimmune pathology. However, the etiology of these specific enamel defects remains unknown. Based on previously reported cross-reactivity of antibodies to gliadin with the enamel proteins, amelogenin and ameloblastin, we analyzed (using immunohistochemistry) the ability of anti-gliadin IgG, produced during untreated disease, to recognize enamel organ structures. We used swine germ teeth as a tissue model because they are highly homologous to human teeth in terms of proteins and development biology. Strong staining of the enamel matrix and of the layer of ameloblasts was observed with serum samples from women with celiac disease; high IgG reactivity was found against both gliadin peptides and enamel matrix protein extract, but there was no IgG reactivity against tissue antigens. In line with these findings, the gamma globulin fraction from gliadin-immunized BALB/c mice showed a similar staining pattern to that of amelogenin-specific staining. These results strongly suggest a pathological role for antibodies to gliadin in enamel defect dentition for both deciduous and permanent teeth, considering that IgG can be transported through the placenta during fetal tooth development. |
| Databáze: | OpenAIRE |
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