Hemostatic function of aspirin-treated platelets vulnerable to cardiopulmonary bypass
| Autor: | Charles R.H. Wildevuur, Leon Eijsman, Rolf C.G. Gallandat Huet, Augueste Sturk, Noriyuki Tabuchi |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Resuscitation Aspirin medicine.diagnostic_test business.industry law.invention medicine.anatomical_structure Bleeding time law Hemostasis Anesthesia Internal medicine medicine Cardiology Cardiopulmonary bypass Platelet Surgery business Hemostatic function Cardiology and Cardiovascular Medicine Artery medicine.drug |
| Zdroj: | The Journal of Thoracic and Cardiovascular Surgery. 110(3):813-818 |
| ISSN: | 0022-5223 |
| DOI: | 10.1016/s0022-5223(95)70115-x |
| Popis: | The impaired hemostasis of aspirin-treated patients is an annoying problem during and after cardiopulmonary bypass. The hemostatic function of platelets comprises two mechanisms: the shear-induced and the cyclooxygenase pathways. Because the latter is inhibited in aspirin-treated patients, the hemostatic function depends mainly on the former pathway. To investigate the effect of cardiopulmonary bypass on the shear-induced pathway, a double-blind study of preoperative aspirin treatment (325 mg) and placebo was conducted in 40 patients undergoing coronary artery bypass grafting. Postoperative blood loss was higher in the aspirin-treated patients than in the placebo-treated patients ( p p p p p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|