Amide proton transfer imaging can predict tumor grade in rectal cancer
| Autor: | Yoshiki Asayama, Minako Hirahashi-Fujiwara, Yasuhiro Ushijima, Eiji Oki, Yuichiro Kubo, Tatsuya Manabe, Akihiro Nishie, Daisuke Okamoto, Kousei Ishigami, Osamu Togao, Daisuke Tsurumaru, Hiroshi Honda, Tomoyuki Hida, Jochen Keupp, Nobuhiro Fujita, Yukihisa Takayama |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Materials science Colorectal cancer Biomedical Engineering Biophysics Amide proton Adenocarcinoma 030218 nuclear medicine & medical imaging 03 medical and health sciences Tumor grade 0302 clinical medicine Nuclear magnetic resonance medicine Humans Effective diffusion coefficient Radiology Nuclear Medicine and imaging Prospective Studies Magnetization transfer Aged Tumor size Rectal Neoplasms Rectum Middle Aged medicine.disease Amides Magnetic Resonance Imaging Diffusion Magnetic Resonance Imaging 030220 oncology & carcinogenesis Female Neoplasm Grading Protons Signal intensity Diffusion MRI |
| Zdroj: | Magnetic Resonance Imaging. 51:96-103 |
| ISSN: | 0730-725X |
| Popis: | Purpose To prospectively investigate the ability of amide proton transfer (APT) imaging, in comparison with that of diffusion-weighted imaging (DWI), to predict pathological factors in rectal cancer. Materials and methods Twenty-two patients who underwent MR examination including APT imaging and DWI for evaluation of rectal cancer were enrolled. APT signal intensity (SI) was defined as the magnetization transfer asymmetry at 3.5 ppm and was mapped. An apparent diffusion coefficient (ADC) map was generated using b-values of 0, 500 and 1000 s/mm2. APT SI and ADC were calculated by placing regions-of-interest in the tumors on these maps. Pathological factors including tumor size and tumor grade were also evaluated. Average APT SIs or ADCs were compared between the two groups classified based on each pathological factor using Student's t-test. Results The average APT SI of tumors with diameters of 5 cm or more (3.09 ± 1.41%) was significantly higher than that of tumors with diameters Conclusion Amide proton transfer imaging can predict tumor grade in rectal cancer. |
| Databáze: | OpenAIRE |
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