| Autor: |
Arvin Halim, Heather N. Burney, Xiaochun Li, Yang Li, Claudia Tomkins, Andrew M. Siedlecki, Tzong-shi Lu, Sahir Kalim, Ravi Thadhani, Sharon Moe, Stephen M.S. Ting, Daniel Zehnder, Thomas F. Hiemstra, Kenneth Lim |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Kidney360 |
| ISSN: |
2641-7650 |
| Popis: |
BACKGROUND: Fibroblast growth factor 23 (FGF23) is a bone-derived phosphatonin that is elevated in chronic kidney disease (CKD) and has been implicated in the development of cardiovascular disease. It is unknown whether elevated FGF23 in CKD is associated with impaired cardiovascular functional capacity, as assessed by maximum exercise oxygen consumption (VO(2)Max). We sought to determine whether FGF23 is associated with cardiovascular functional capacity in patients with advanced CKD and after improvement of VO(2)Max by kidney transplantation. METHODS: We performed secondary analysis of 235 patients from the Cardiopulmonary Exercise Testing in Renal Failure and After Kidney Transplantation (CAPER) cohort, which recruited patients with stage 5 CKD who underwent kidney transplantation or were waitlisted and hypertensive controls. All patients underwent cardiopulmonary exercise testing (CPET) and echocardiography and were followed longitudinally for 1 year after study enrollment. RESULTS: Patients across FGF23 quartiles differed in BMI (P=0.004) and mean arterial pressure (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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