The Effect of Different Storage Conditions on the Chemical Stability, Laxative Effect and Acute Toxicity of Sennoside Solutions
| Autor: | Martti Marvola, Heli Lainonen, Tuuli Parviainen, Pentti Hietala |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Sennosides
Hot Temperature Time Factors Drug Storage Health Toxicology and Mutagenesis medicine.medical_treatment Laxative Cathartic Anthraquinones Toxicology 030226 pharmacology & pharmacy Dosage form Mice 03 medical and health sciences 0302 clinical medicine Drug Stability medicine Animals Potency Pharmacology Aqueous solution Chromatography Cathartics Chemistry Senna Extract Hydrogen-Ion Concentration Acute toxicity Toxicity Female Chemical stability 030217 neurology & neurosurgery |
| Zdroj: | Pharmacology & Toxicology. 63:37-41 |
| ISSN: | 1600-0773 0901-9928 |
| DOI: | 10.1111/j.1600-0773.1988.tb00906.x |
| Popis: | This paper investigates the effect of different storage conditions on the chemical stability, laxative effect and acute toxicity of sennoside solutions. The variables in storage conditions were pH, time and temperature (room temperature or 100 degrees). The chemical stability of sennosides in aqueous solutions was found to be pH-dependent, with the best stability at pH 6.5 (t90. = 8.4 months) and the poorest at pH 8.0 (t90. = 2.5 months). Two years of storage at room temperature did not reduce the laxative potency in mice, regardless of the pH. After 4.25 years of storage the potency declined in alkaline solutions only. The degradation products with laxative potencies are chemically unknown. The acute toxicity of sennoside solutions increased with time during storage, the acid solution being more toxic than either the neutral or alkaline ones. |
| Databáze: | OpenAIRE |
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