Perinatal outcomes in children born after fresh or frozen embryo transfer: a Catalan cohort study based on 14,262 newborns

Autor: Ana Robles, Kilian Vellvé, Ramon Carreras, Miguel A. Checa, Maria Prat, Mireia González-Comadran, Mar Torné, Mar Vidal
Rok vydání: 2017
Předmět:
Adult
Male
0301 basic medicine
medicine.medical_specialty
Population
Gestational Age
Fertilization in Vitro
03 medical and health sciences
0302 clinical medicine
Ovulation Induction
Risk Factors
medicine
Birth Weight
Humans
Registries
education
Perinatal Mortality
Retrospective Studies
Cryopreservation
Gynecology
education.field_of_study
030219 obstetrics & reproductive medicine
Oocyte Donation
Obstetrics
business.industry
Infant
Newborn
Obstetrics and Gynecology
Gestational age
Retrospective cohort study
Infant
Low Birth Weight
Embryo Transfer
medicine.disease
Vitrification
Embryo transfer
Fertility
Treatment Outcome
030104 developmental biology
Reproductive Medicine
Spain
Premature birth
Infertility
Infant
Small for Gestational Age
Premature Birth
Small for gestational age
Female
Live birth
business
Live Birth
Cohort study
Zdroj: Fertility and Sterility. 107:940-947
ISSN: 0015-0282
DOI: 10.1016/j.fertnstert.2017.01.021
Popis: Objective To ascertain whether perinatal outcomes are affected by vitrification and/or controlled ovarian hyperstimulation (COH). Design Register-based cohort study. Setting Not applicable. Patient(s) Women undergoing in vitro fertilization (IVF) between 2008 and 2012 using autologous or donated eggs who had a singleton pregnancy delivered from the 24th week onward. Intervention(s) Fresh embryo transfer (ET) or frozen-thawed ET in women undergoing IVF. Main Outcome Measure(s) Primary outcome birthweight, and secondary outcomes gestational age at delivery, small for gestational age, mode of delivery, and perinatal mortality. Result(s) In the autologous egg population, newborns from the fresh ET group had lower birthweight than the frozen-thawed ET group (3,152.9 ± 545.5g and 3,343.2 ± 532.3g, respectively), and this difference persisted even after adjusting for confounding factors, and the newborns had a higher risk of being small for gestational age (SGA). In contrast, among egg-donor recipients undergoing ET, the mean birthweight did not differ between the groups (3,165 ± 604.15 g and 3,143.60 ± 604.21g in the fresh and frozen-thawed ET groups, respectively); however, in the adjusted regression model birthweight was statistically significantly higher in the fresh ET group than the frozen-thawed ET group. The risk of SGA remained comparable between the fresh versus frozen-thawed ET groups. We observed no statistically significant differences in perinatal mortality between groups either in the autologous egg population or in the donor recipient group. Conclusion(s) Perinatal outcomes are negatively affected by COH and not affected by the vitrification process.
Databáze: OpenAIRE
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