Induction of FoxP3+CD4+CD25+ regulatory T cells by a bone marrow population distinct from plasmacytoid-DC
| Autor: | Yolonda L. Colson, Monika Laszkowska, Kendra N. Taylor, Evan Cohick |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Regulatory T cell
Cellular differentiation Immunology Gene Expression Bone Marrow Cells chemical and pharmacologic phenomena Biology T-Lymphocytes Regulatory Article Interferon-gamma Mice Interleukin 21 T-Lymphocyte Subsets Transforming Growth Factor beta medicine Animals RNA Messenger IL-2 receptor Cells Cultured Interleukin-2 Receptor alpha Subunit Hematopoietic stem cell FOXP3 Cell Differentiation Forkhead Transcription Factors hemic and immune systems Dendritic Cells Coculture Techniques Cell biology Mice Inbred C57BL Transplantation medicine.anatomical_structure Toll-Like Receptor 9 CD4 Antigens Genes T-Cell Receptor beta Cytokines Female Stem cell |
| Zdroj: | Cellular Immunology. 251:43-49 |
| ISSN: | 0008-8749 |
| Popis: | Facilitating cells (FC) are bone marrow-derived cells that facilitate allogeneic hematopoietic stem cell (SC) engraftment and induce transplantation tolerance without causing graft vs. host disease. Although there is evidence for FC directing the development of FoxP3+CD4+CD25+ regulatory T cells, the specific FC subsets that control regulatory T cell development have not been defined. The current study investigates the role of FC-CD3epsilon+ and FC-CD3epsilon- subpopulations in the development of FoxP3+CD4+CD25+ regulatory T cells. Here, we demonstrate that the induction of FoxP3+CD4+CD25+ regulatory T cells in coculture is mediated by not only the FC-CD3epsilon- subset but also the FC-CD3epsilon+ subset, which is distinct from plasmacytoid precursor dendritic cells (p-preDC). The identification of cell populations distinct from p-preDC that efficiently induce the generation of FoxP3+CD4+CD25+ regulatory T cells may prove useful for future therapeutic applications for the induction of tolerance following allogeneic SC transplantation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect