Eight thousand years of natural selection in Europe
| Autor: | Harald Meller, Bastien Llamas, Johannes Krause, de Castro Jmb, Roodenberg J, David Reich, Fokke Gerritsen, Kristin Stewardson, Pavel Kuznetsov, Joseph K. Pickrell, Mario Novak, Eppie R. Jones, David W. Anthony, Rojo Guerra Ma, Alpaslan Roodenberg S, Eadaoin Harney, Josep Maria Vergès, Iain Mathieson, Oleg Mochalov, Kurt W. Alt, Moiseyev, Ron Pinhasi, Carles Lalueza-Fox, Eudald Carbonell, Marina Lozano, Nadine Rohland, Cristina Gamba, Dorcas Brown, Daniel Fernandes, Mallick S, Wolfgang Haak, Kendra Sirak, Stanislav Dryomov, Aleksander Khokhlov, Iosif Lazaridis, Alan Cooper, Juan Luis Arsuaga, Nick Patterson |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Genetics
0303 health sciences education.field_of_study Natural selection Population Biology Indirect evidence 03 medical and health sciences 0302 clinical medicine Ancient DNA Evolutionary biology Genetic variation Adaptation education Social organization 030217 neurology & neurosurgery Selection (genetic algorithm) 030304 developmental biology |
| DOI: | 10.1101/016477 |
| Popis: | The arrival of farming in Europe around 8,500 years ago necessitated adaptation to new environments, pathogens, diets, and social organizations. While indirect evidence of adaptation can be detected in patterns of genetic variation in present-day people, ancient DNA makes it possible to witness selection directly by analyzing samples from populations before, during and after adaptation events. Here we report the first genome-wide scan for selection using ancient DNA, capitalizing on the largest genome-wide dataset yet assembled: 230 West Eurasians dating to between 6500 and 1000 BCE, including 163 with newly reported data. The new samples include the first genome-wide data from the Anatolian Neolithic culture, who we show were members of the population that was the source of Europe's first farmers, and whose genetic material we extracted by focusing on the DNA-rich petrous bone. We identify genome-wide significant signatures of selection at loci associated with diet, pigmentation and immunity, and two independent episodes of selection on height. |
| Databáze: | OpenAIRE |
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