Rearterialization of liver tumors after various dearterialization procedures
| Autor: | Bo G. Persson, Lennart Bergqvist, Li-Qing Wang, Stig Bengmark |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Urology Hemodynamics Microsphere Hepatic Artery Medicine Animals Tumor growth Rats Wistar Ligation Hepatic artery ligation Neovascularization Pathologic business.industry Liver Neoplasms Arterial blood flow Blood flow Arteries Surgery Rats Regional Blood Flow Circulatory system business Liver Circulation |
| Zdroj: | The Journal of surgical research. 57(4) |
| ISSN: | 0022-4804 |
| Popis: | Repeat dearterializations seem to be a means to prevent collateral formation, which is partly responsible for the failure of hepatic artery ligation (HAL) or permanent dearterialization when used to treat liver tumors. In this study restoration of tumor blood flow was evaluated after various procedures: HAL (n = 12), permanent dearterialization (n = 18), repeated dearterializations for 2 hr/day (n = 12), and sham dearterialization (n = 12). Tumor blood flow was measured 10 days after sham dearterialization, permanent dearterialization, and repeated dearterializations for 2 hr in order to further illustrate the effect of prolonged dearterialization on tumor rearterialization. Hepatic and tumor arterial blood flow was measured using the reference organ method (NEN, Ce-141 microspheres with diameter 15 mu m). Our results showed that during a transient dearterialization blood flow decreased to 1% (0.01 +/- 0.01 ml/min/g) of the flow in the controls (0.82 +/- 0.10 ml/min/g) (P < 0.01). After HAL tumor blood flow recovered to initial levels after 48 hr (0.73 +/- 0.17 ml/min/g. Even in rats subjected to a permanent dearterialization blood flow was reestablished at Day 6 (0.59 +/- 0.21 ml/min/g). In contrast, after repeat daily 2-hr dearterializations blood flow remained significantly very low during the 6th transient dearterialization (0.11 +/- 0.03 ml/min/g) compared with both sham-operation and HAL as well as permanent dearterialization (P < 0.01). During the 10th daily dearterialization tumor blood flow was still significantly low compared with both controls (P < 0.001) and permanent dearterialization (P < 0.05). Our results indicate that both HAL and permanent dearterialization are inefficient to prevent rearterialization of tumor, although permanent dearterialization may keep blood flow reduced for a few days. However, repeat dearterializations significantly delay tumor growth and prevent tumor rearterialization for a prolonged period. (C) 1994 Academic Press, Inc. |
| Databáze: | OpenAIRE |
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