Detection of relevant pharmacogenetic information through exome sequencing in oncology

Autor:	Simon Verdez, Juliette Albuisson, Yannis Duffourd, Romain Boidot, Manon Reda, Christel Thauvin-Robinet, Jean-David Fumet, Sylvain Ladoire, Sophie Nambot, Patrick Callier, Laurence Faivre, François Ghiringhelli, Nicolas Picard
Rok vydání:	2022
Předmět:	Analgesics Opioid Pharmacology Cytochrome P-450 CYP2D6 Drug-Related Side Effects and Adverse Reactions Genotype Pharmacogenetics Genetics Antiemetics Humans Molecular Medicine Exome Fluorouracil Retrospective Studies
Zdroj:	Pharmacogenomics. 23:759-770
ISSN:	1744-8042 1462-2416
Popis:	Background: Germline sequencing of individual genomes can detect alleles responsible for adverse drug reactions (ADRs) in relation to chemotherapy, targeted agents, antiemetics or pain treatment. Materials & methods: To evaluate the interest of such pharmacogenetic information, the authors retrospectively analyzed genes known to have an impact on cancer therapy in a cohort of 445 solid cancers patients. Results: Six patients treated with 5-fluorouracil carrying one DPYD variant classified as 1A showed decreased drug mean clearance (p = 0.01). Regarding CYP2D6, all patients (n = 5) with predicted CYP2D6 poor or ultra-rapid metabolizer status experienced adverse drug reactions related to opioid therapy. Conclusion: Genomic germline sequencing performed for theragnostic issues in patients with a solid tumor, can provide relevant information about common pharmacogenetic alleles.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2699a0cd3351ba563af211d9e982445 https://doi.org/10.2217/pgs-2022-0085 Zobrazit plný text záznamu