Methimazole-induced myositis: a case report and review of the literature
| Autor: | Ghada Abdallah, R Bou Khalil, J Hreiki, E Azar, S Sissi, M Abou Salbi, M Khoury, N El Kara, Said Farhat |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
myalgia
medicine.medical_specialty business.industry Endocrinology Diabetes and Metabolism Graves' disease Context (language use) medicine.disease Dermatology Surgery Carbimazole Internal Medicine medicine Unusual Effects of Medical Treatment Eosinophilia medicine.symptom Vasculitis business Fasciitis Myositis medicine.drug |
| Zdroj: | Endocrinology, Diabetes & Metabolism Case Reports |
| ISSN: | 2052-0573 |
| Popis: | SummaryMethimazole is an anti-thyroid drug commonly used to treat hyperthyroidism and is a relatively safe medication. Several side effects have been reported and usually develop within 3 months of therapy. Well-known adverse reactions include agranulocytosis, hepatitis, skin eruptions, and musculoskeletal complaints such as myalgia, arthralgia, and arthritis. So far, myositis secondary to carbimazole was described in the context of a lupus-like syndrome or other rare cases of anti-neutrophil cytoplasmic antibodies-associated vasculitis. Methimazole-induced myositis occurring independently of such reactions was rarely stated. We report a patient with hyperthyroidism who, early after therapy with methimazole, developed hepatitis, eosinophilia, and fever that resolved completely after stopping the medication as well as a delayed onset of biopsy-proven eosinophilic myositis and fasciitis of gluteal muscles that resolved eventually without any additional therapy. Therefore, we raise the awareness regarding a rare side effect of methimazole: myositis.Learning pointsSeveral differential diagnoses arise when managing a hyperthyroid patient with muscle complaints.Both hyperthyroidism and methimazole are associated with myositis.Methimazole-induced myositis is a rare clinical entity.Resolution of symptoms may occur after stopping methimazole. |
| Databáze: | OpenAIRE |
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