Phenotype Difference between Familial and Sporadic Ankylosing Spondylitis in Korean Patients
| Autor: | Jisue Kang, Hye Won Kim, Yeong Wook Song, Jin Young Moon, Won Ik Chang, Hyun Jun Chae, Eun Young Lee, Sungim Lee, Hye Rim Choe, Su Bin Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Blood Sedimentation Gastroenterology Severity of Illness Index Body Mass Index Interviews as Topic Immunology Allergic Disorders & Rheumatology Familial Sex Factors Recurrence Risk Factors Internal medicine Severity of illness Republic of Korea medicine Humans Spondylitis Ankylosing Family Spondylitis HLA-B27 Antigen Demography Ankylosing spondylitis Oligoarthritis biology medicine.diagnostic_test business.industry C-reactive protein Age Factors General Medicine Middle Aged medicine.disease Sporadic Arthritis Juvenile Surgery Phenotype C-Reactive Protein Erythrocyte sedimentation rate Familial history biology.protein Recurrence Risk Original Article Female business Body mass index |
| Zdroj: | Journal of Korean Medical Science |
| ISSN: | 1598-6357 1011-8934 |
| Popis: | Clustered occurrences of ankylosing spondylitis (AS) in family have been noticed. We evaluated patients with AS confirmed by the modified New York criteria for familial history of AS (one or more first to third degree relatives). The clinical characteristics and the recurrence risks (number of AS patients/number of familial members) of the familial AS compared to sporadic AS were investigated. Out of a total of 204 AS patients, 38 patients (18.6%) reported that they had a familial history of AS. The recurrence risks in the familial AS patients for first, second and third degree family members were 14.5%, 5.2%, and 4.4% respectively. Erythrocyte sedimentation rate (ESR) (22.6±22.2 vs 35.4±34.4, P=0.029) and C-reactive protein (CRP) (1.24±1.7 vs 2.43±3.3, P=0.003) at diagnosis, body mass index (21.9±2.7 vs 23.7±3.3, P=0.002) and frequency of oligoarthritis (13.2% vs 33.7%, P=0.021) were significantly lower in the familial form. The presence of HLA-B27 (97.4% vs 83.1%, P=0.044) was significantly higher in familial AS. In conclusion, Korean familial AS patients show a lower frequency of oligoarthritis, lower BMI, lower ESR and CRP at diagnosis and higher presence of HLA-B27. Graphical Abstract |
| Databáze: | OpenAIRE |
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