Diffusion-weighted MRI of the prostate without susceptibility artifacts: Undersampled multi-shot turbo-STEAM with rotated radial trajectories
| Autor: | Sabine Hofer, Klaus-Dietmar Merboldt, Andreas Merrem, Zhengguo Tan, Ali Seif Amir Hosseini, Jens Frahm, Dirk Voit |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Rotation Turbo Iterative reconstruction Signal-To-Noise Ratio Imaging phantom 030218 nuclear medicine & medical imaging 03 medical and health sciences Prostate cancer 0302 clinical medicine Prostate medicine Humans Effective diffusion coefficient Radiology Nuclear Medicine and imaging Spectroscopy Physics biology Echo-Planar Imaging Phantoms Imaging business.industry Healthy subjects medicine.disease biology.organism_classification Diffusion Magnetic Resonance Imaging medicine.anatomical_structure Molecular Medicine Artifacts Nuclear medicine business 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | NMR in Biomedicine |
| Popis: | The aim of this study was to develop and evaluate a clinically feasible approach to diffusion-weighted (DW) MRI of the prostate without susceptibility-induced artifacts. The proposed method relies on an undersampled multi-shot DW turbo-STEAM sequence with rotated radial trajectories and a multi-step inverse reconstruction with denoised multi-shot phase maps. The total acquisition time was below 6 min for a resolution of 1.4 × 1.4 × 3.5 mm3 and six directions at b = 600 s mm-2 . Studies of eight healthy subjects and two patients with prostate cancer were performed at 3 T employing an 18-channel body-array coil and elements of the spine coil. The method was compared with conventional DW echo-planar imaging (EPI) of the prostate. The results confirm that DW STEAM MRI avoids geometric distortions and false image intensities, which were present for both single-shot EPI (ssEPI) and readout-segmented EPI, particularly near the intestinal wall of the prostate. Quantitative accuracy of the apparent diffusion coefficient (ADC) was validated with use of a numerical phantom providing ground truth. ADC values in the central prostate gland of healthy subjects were consistent with those measured using ssEPI and with literature data. Preliminary results for patients with prostate cancer revealed a correct anatomical localization of lesions with respect to T2 -weighted MRI in both mean DW STEAM images and ADC maps. In summary, DW STEAM MRI of the prostate offers clinically relevant advantages for the diagnosis of prostate cancer compared with state-of-the-art EPI-based approaches. The method warrants extended clinical trials. |
| Databáze: | OpenAIRE |
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