Long-Term Outcomes and Health-Related Quality of Life in a Swiss Patient Group with Esophageal Atresia
| Autor: | Andrea A. Mauracher, Jessica Brestel, Anthony di Natale, Ueli Möhrlen, Ulrike Subotic, Sasha J. Tharakan, Martin Meuli |
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| Přispěvatelé: | University of Zurich, di Natale, Anthony |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Adult
Pediatrics medicine.medical_specialty Adolescent MEDLINE 610 Medicine & health Disease 03 medical and health sciences 0302 clinical medicine Quality of life Surveys and Questionnaires 030225 pediatrics medicine Long term outcomes Humans In patient 10220 Clinic for Surgery 2735 Pediatrics Perinatology and Child Health Patient group Child Esophageal Atresia Health related quality of life business.industry medicine.disease 2746 Surgery Child Preschool Esophagoplasty Atresia Pediatrics Perinatology and Child Health Quality of Life 030211 gastroenterology & hepatology Surgery business Switzerland |
| DOI: | 10.5167/uzh-216166 |
| Popis: | Introduction Surgical treatment of esophageal atresia (EA) has markedly improved, allowing the focus to shift from short-term complications and mortality to long-term complications and quality of life. Health-related quality of life (HRQoL) is variable and reported to range from reduced to unimpaired in patients with repaired EA. We assessed the HRQoL, determined the prevalence of long-term complications and their possible impact on the HRQoL in patients who had correction of EA in Switzerland. Further, we also investigated in the general well-being of their parents. Materials and Methods Patients with EA repair in Switzerland between 1985 and 2011 were enrolled. Long-term complications were assessed by enquiring disease-related symptoms, standardized clinical examinations, and analysis of radiographs. HRQoL was inquired using different validated questionnaires (KIDSCREEN-27, World Health Organization [WHO]-5, and Gastrointestinal Quality of Life Index [GIQLI]). Patients were grouped according to their age. In underage patients, general well-being of the parents was assessed using the WHO-5 questionnaire. Results Thirty patients were included with a mean age of 11.3 ± 5.7 years. Long-term complications were present in 63% of all patients. HRQoL in underage patients was comparable to the provided reference values and rated as good, while adult patients reported a reduced HRQoL. The presence of gastroesophageal reflux disease symptoms was associated with reduced HRQoL in underage patients. Parents of underage patients stated a good general well-being. Conclusion Long-term complications among patients with repair of EA in Switzerland are common. HRQoL in underage patients is good and general well-being of their parents is unimpaired. Adult patients reported a reduced HRQoL, consistent with other reports. As long-term complications may manifest only later in life, a structured follow-up of patients with an EA repair during childhood and adolescence is needed. |
| Databáze: | OpenAIRE |
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