Sex and hormonal modification of 6-keto-PGF1α release by rat aorta
| Autor: | E. R. Ramey, Peter W. Ramwell, Kenneth Pomerantz, Franco Maggi, Y T Maddox |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Male
medicine.medical_specialty Prostacyclin 6-Ketoprostaglandin F1 alpha In Vitro Techniques Biology General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound medicine.artery Internal medicine medicine Animals Testosterone Castration General Pharmacology Toxicology and Pharmaceutics Incubation Aorta Progesterone Ovariectomized female Sex Characteristics Estradiol Prostaglandins F General Medicine Hormones Rats Endocrinology chemistry Blood Vessels Female lipids (amino acids peptides and proteins) 6 keto pgf1α medicine.drug Hormone |
| Zdroj: | Life Sciences. 27:1233-1236 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(80)90477-4 |
| Popis: | The stable breakdown product of prostacyclin, 6-keto-PGF1α, was estimated in plasma samples after incubation with rat aortic rings. The 6-keto-PGF1α concentration obtained with the male aortae was two-fold higher than that of the female. Ovariectomy markedly increased 6-keto-PGF1α six-fold, but castration had no effect. Estradiol and progesterone treatment of the ovariectomized female suppressed (by 50%) and enhanced (two-fold) 6-keto-PGF1α. Testosterone was without effect in gonadectomized males and females. Castrate males did not respond to gonadal steroid treatment. |
| Databáze: | OpenAIRE |
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