Monocyte-Derived CD11c(+) Cells Acquire Plasmodium from Hepatocytes to Prime CD8 T Cell Immunity to Liver-Stage Malaria
| Autor: | Lisa S. Hancox, Lecia L. Pewe, Samarchith P. Kurup, John T. Harty, Shahid M. Khan, Chris J. Janse, Scott M. Anthony, Ramakrishna Sompallae, Rahul Vijay, Steven J Moioffer |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
CD11c Priming (immunology) Biology medicine.disease Microbiology Virology 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Antigen Immunity Hepatocyte parasitic diseases medicine Cytotoxic T cell Parasitology 030217 neurology & neurosurgery CD8 Malaria 030304 developmental biology |
| Zdroj: | Cell Host and Microbe, 25(4), 565-+. CELL PRESS |
| Popis: | Summary Plasmodium sporozoites inoculated by mosquitoes migrate to the liver and infect hepatocytes prior to release of merozoites that initiate symptomatic blood-stage malaria. Plasmodium parasites are thought to be restricted to hepatocytes throughout this obligate liver stage of development, and how liver-stage-expressed antigens prime productive CD8 T cell responses remains unknown. We found that a subset of liver-infiltrating monocyte-derived CD11c+ cells co-expressing F4/80, CD103, CD207, and CSF1R acquired parasites during the liver stage of malaria, but only after initial hepatocyte infection. These CD11c+ cells found in the infected liver and liver-draining lymph nodes exhibited transcriptionally and phenotypically enhanced antigen-presentation functions and primed protective CD8 T cell responses against Plasmodium liver-stage-restricted antigens. Our findings highlight a previously unrecognized aspect of Plasmodium biology and uncover the fundamental mechanism by which CD8 T cell responses are primed against liver-stage malaria antigens. |
| Databáze: | OpenAIRE |
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