In vivo Aneuploidization during the Expansion of Renal Adenocarcinoma
| Autor: | C. Di Capua Sacoto, J.L. Ruiz Cerdá, A. Budía Alba, J.M. Alapont Alacreu, J.F. Jiménez Cruz |
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| Rok vydání: | 2011 |
| Předmět: |
Pathology
medicine.medical_specialty Urology Primary tumor size Biology In vivo medicine Tumor Expansion Humans Carcinoma Renal Cell Neoplasm Staging Retrospective Studies Cell Nucleus Ploidies Advanced stage Histology DNA DNA Neoplasm Aneuploidy Flow Cytometry Prognosis Diploidy Kidney Neoplasms stomatognathic diseases Homogeneous Renal adenocarcinoma Ploidy |
| Zdroj: | Urologia Internationalis. 86:466-469 |
| ISSN: | 1423-0399 0042-1138 |
| DOI: | 10.1159/000324101 |
| Popis: | Background/Aims: A correlation has been observed between DNA ploidy and other prognostic parameters such as tumor stage and grade. The present study evaluates tumor aneuploidization during renal adenocarcinoma expansion and growth. Methods: A total of 252 renal tumors were analyzed between 1969 and 2001. Evaluated variables were age, TNM, Fuhrman classification, histology, size and DNA. A tumor was homogeneous when all the samples were diploid or aneuploid, and a heterogeneous tumor was the coexistence of aneuploid and diploid samples, or all-aneuploid with different aneuploid clones. Results: A total of 224 tumors were included (coefficient of variation Conclusions: The aneuploid pattern is more common in more advanced stages of the disease, with no clear correlation to primary tumor size. This suggests gradual aneuploidization with tumor expansion and growth. |
| Databáze: | OpenAIRE |
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