Low dose dabigatran versus uninterrupted acenocoumarol for peri-procedural anticoagulation in atrial fibrillation catheter ablation
| Autor: | Spyridon Deftereos, Stamatis Georgopoulos, Antonios Sideris, Maria Vadiaka, Konstantinos P. Letsas, Georgios Giannopoulos, Louiza Lioni, Konstantinos Vlachos, Michael Efremidis |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Premedication medicine.medical_treatment Catheter ablation Postoperative Hemorrhage Drug Administration Schedule Pulmonary vein Dabigatran Internal medicine Atrial Fibrillation Humans Medicine Acenocoumarol Dose-Response Relationship Drug business.industry Anticoagulants Thrombosis Atrial fibrillation Heparin Middle Aged medicine.disease Regimen Treatment Outcome Hemostasis Anesthesia Catheter Ablation Cardiology Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of Electrocardiology. 48:840-844 |
| ISSN: | 0022-0736 |
| DOI: | 10.1016/j.jelectrocard.2015.06.011 |
| Popis: | Left atrial ablation for atrial fibrillation (AF) is associated with a transiently increased risk of thromboembolic and hemorrhagic events. We tested the hypothesis that the low dose dabigatran [110mg twice a day (bid)] can be safely used as an alternative to uninterrupted acenocoumarol for periprocedural anticoagulation in left atrial ablation procedures.A total of 149 consecutive patients undergoing pulmonary vein antral isolation for AF were included; 64 patients were on low dose dabigatran (110mg bid) and 85 patients were on acenocoumarol with therapeutic international normalized ratios. Two doses of dabigatran were withheld before the procedure and the drug was restarted 4hours after vascular hemostasis. Overall, the two groups were well-matched. Hemorrhagic and thromboembolic complications were similar in both groups within 90days from the procedure (4.7% for the dabigatran group versus 9.4% for the acenocoumarol group; P=0.275). Major hemorrhage occurred in 1.6% in the dabigatran group versus 3.5% in the acenocoumarol group (P=0.462). A single thromboembolic event occurred in the dabigatran group (1.6%) versus 2 (2.4%) in the acenocoumarol group (P=0.734). Despite higher doses of intraprocedural heparin (P0.01), the mean activated clotting time was significantly lower in patients who were on dabigatran than those on acenocoumarol (P0.01).The low dose dabigatran regimen provides safe and effective peri-procedural anticoagulation in patients undergoing left atrial ablation for AF compared with uninterrupted acenocoumarol therapy. |
| Databáze: | OpenAIRE |
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