A pilot study of oxaliplatin with oral S-1 as second-line chemotherapy for patients with recurrent adenocarcimona of the uterine cervix

Autor: Masahiro Kagabu, Toru Sugiyama, Yuki Miura, Eriko Takatori, Anna Takada, Tadahiro Shoji, Hanae Niinuma, Yasuko Suga, Yoshitaka Kaido, Satoshi Takeuchi
Rok vydání: 2013
Předmět:
Zdroj: International Journal of Clinical Oncology. 19:336-340
ISSN: 1437-7772
1341-9625
DOI: 10.1007/s10147-013-0539-4
Popis: The efficacy and safety of S-1/oxaliplatin (SOX) therapy in patients with recurrent adenocarcinoma of the uterine cervix were examined in a pilot study. S-1 was orally administered for 14 days at a dose of 80–120 mg/body/day to 7 patients with recurrent adenocarcinoma of the uterine cervix, with oxaliplatin being administered intravenously at a dose of 100 mg/m2 on day 1. Each therapy cycle was 21 days, and the patients received 6 cycles at most. The antitumor effect, adverse events, progression-free survival (PFS), and overall survival (OS) were investigated. The median age of the patients was 49 years. The antitumor effect was rated as a complete response in 2 patients, partial response in 2, and stable disease in 3. The overall response rate was 57.1 %, and the disease control rate was 100 %. Regarding hematological toxicities of grade 3 or more, leukopenia, neutropenia and thrombocytopenia occurred in 42.9, 28.6 and 14.3 %, respectively; regarding non-hematological toxicities, grade 3 rectovaginal fistula occurred in 14.3 %, as well as grade 2 fatigue in 14.3 % of the patients. The median PFS and OS were 5 months (range 3–9 months) and 7 months (range 4–43 months), respectively. These results suggest that SOX therapy is useful for the treatment of recurrent adenocarcinoma of the uterine cervix, having a promising antitumor effect and minimal adverse effects. It was also suggested that SOX therapy may contribute to improving the prognosis for patients with adenocarcinoma of the uterine cervix.
Databáze: OpenAIRE
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