APC/C and retinoblastoma interaction: cross-talk of retinoblastoma protein with the ubiquitin proteasome pathway
| Autor: | Ajeena Ramanujan, Swati Tiwari |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Proteasome Endopeptidase Complex Ubiquitin-Protein Ligases Biophysics Mitosis Apoptosis Review Article Biochemistry Retinoblastoma Protein retinoblastoma Anaphase-Promoting Complex-Cyclosome Cdh1 Proteins APC/C activator protein CDH1 FZR1 03 medical and health sciences Ubiquitin human papilloma virus medicine Humans Molecular Biology Review Articles Cell Proliferation anaphase promoting complex/cyclosome biology Retinoblastoma Retinoblastoma protein G1 Phase Cell Differentiation Cell Biology Cell cycle medicine.disease Cell biology Ubiquitin ligase LxCxE 030104 developmental biology Proteasome biology.protein cell cycle Anaphase-promoting complex |
| Zdroj: | Bioscience Reports |
| ISSN: | 1573-4935 0144-8463 |
| Popis: | The ubiquitin (Ub) ligase anaphase promoting complex/cyclosome (APC/C) and the tumour suppressor retinoblastoma protein (pRB) play key roles in cell cycle regulation. APC/C is a critical regulator of mitosis and G1-phase of the cell cycle whereas pRB keeps a check on proliferation by inhibiting transition to the S-phase. APC/C and pRB interact with each other via the co-activator of APC/C, FZR1, providing an alternative pathway of regulation of G1 to S transition by pRB using a post-translational mechanism. Both pRB and FZR1 have complex roles and are implicated not only in regulation of cell proliferation but also in differentiation, quiescence, apoptosis, maintenance of chromosomal integrity and metabolism. Both are also targeted by transforming viruses. We discuss recent advances in our understanding of the involvement of APC/C and pRB in cell cycle based decisions and how these insights will be useful for development of anti-cancer and anti-viral drugs. |
| Databáze: | OpenAIRE |
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