The pathogenesis of post-obstructive diuresis. The role of circulating natriuretic and diuretic factors, including urea
| Autor: | W E Yarger, R H Harris |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1975 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Renal function Diuresis Natriuresis Blood Pressure urologic and male genital diseases Anuria Kidney Nephrectomy Excretion Internal medicine medicine Animals Urea Aminohippuric acid Chemistry Aminohippuric Acids Sodium Inulin General Medicine Rats medicine.anatomical_structure Endocrinology Potassium Diuretic medicine.symptom medicine.drug Research Article Glomerular Filtration Rate Ureteral Obstruction |
| Popis: | To investigate the pathogenesis of post-obstructive diuresis, a state of functional "anuria" during ureteral obstruction was created in awake rats by (a) bilateral obstruction (BO); (b) unilateral obstruction and contralateral nephrectomy (UO-Nx); or (c) unilateral obstruction and continuous i.v. reinfusion of urine from the intact contralateral kidney (UO-reinf). These groups were compared with unilaterally obstructed (UO) and sham-operated control (sham) rats. After release of obstruction of 24 h duration, mean urine flows (V) and sodium excretion rates (UNaV) were significantly elevated above those of sham rats in BO, UO-Nx, and UO-reinf animals, but slightly decreased in UO rats. Glomerular filtration rates were comparably depressed in UO, BO, UO-Nx, and UO-reinf rats. These results suggest that post-obstructive diuresis is due to one or more circulating diuretic factors that are normally excreted in the urine, and which, when retained )as in BO or UO-Nx rats) or returned to the circulation (as in UO-reinf rats), exert a diuretic affect. In additional experiments, UO rats infused with urea exhibited post-obstructive diuresis, if extracellular volume contraction was prevented. This result suggests that urea may be an important diuretic factor in post-obstructive diuresis, but does not exclude possible roles for other humoral factors. The intact kidney of UO-reinf rats displayed a massive unilateral diuresis and natriuresis, further suggesting the presence of potent diuretic factors in the urine. A marked increase in the fractional excretion of glomerular filtrate (V/GFR) by the intact kidney suggests that this diuresis may be attributable, in part, to impaired proximal reabsorption. |
| Databáze: | OpenAIRE |
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