Autoimmune Hepatitis in Cuban Patients: A Retrospective Analysis of Clinical and Histological Profiles, Treatments, and Outcomes
| Autor: | Ana Luisa Torres González, Zaily Dorta Guridi, Maria Edelina Cepeda Mullo, Deyanira La Rosa Hernández, Marlen Ivón Castellanos Fernández, Robert G. Gish, Licet González Fabián, Héctor Vega Sánchez |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Complications Survival Population Autoimmune hepatitis Asymptomatic 03 medical and health sciences Liver disease 0302 clinical medicine Interquartile range Prednisone Internal medicine Azathioprine Medicine Pharmacology (medical) education Original Research Subclinical infection Pharmacology education.field_of_study business.industry lcsh:RM1-950 Retrospective cohort study Follow up medicine.disease lcsh:Therapeutics. Pharmacology 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology medicine.symptom business medicine.drug |
| Zdroj: | Current Therapeutic Research, Vol 93, Iss, Pp 100594-(2020) Current Therapeutic Research, Clinical and Experimental |
| Popis: | Background Population-based studies on the clinical course and prognosis of autoimmune hepatitis (AIH) from Caribbean countries are limited. Objective The aim of this study was to provide information regarding the clinical and laboratory findings, histological profile, treatments, and outcomes of patients with AIH with long-term follow-up in a tertiary referral center. Methods A retrospective study was performed at the National Institute of Gastroenterology in Havana, Cuba, by enrolling 82 patients with a well-documented, long-term clinical course of AIH. Clinical and laboratory findings, histological profiles, treatments, and outcomes were analyzed. Results At diagnosis, 73 (89%) patients had AIH type 1, 84.1% were women, and their median age was 46.5 years (range, 17–79 years). The median follow-up period was 84 months (interquartile range, 12–276 months). Clinical onset was mild or subclinical in 72% of patients and asymptomatic in 12.2%. At diagnosis, the Hennes's median score was 6 (range, 3–8). Complications were seen in 44 (53.6%) patients, 42 (51.2%) with liver-related complications and 9 (10.9%) without liver-related complications. Cirrhosis was present at diagnosis in 32 (39%) patients. Cirrhosis was subsequently diagnosed in the other 28 patients who were not cirrhotic at diagnosis, over a median follow-up of 12 (IQR, 2-84) months. During follow-up, 6 patients died (7.3%). Cumulative survival at 5 and 10 years was 98.4% and 89%, respectively. A complete biochemical response was achieved in 79% of patients in a mean (SD) of 11.7 (11.6) months. Side effects due to treatment were reported in 76 (92.7%) patients, and no pretreatment factors were found to predict treatment response. Conclusions These Cuban patients with AIH had acceptable disease remission rate and a prompt treatment response. Although most patients had advanced-stage liver disease at diagnosis or developed during follow-up, the cumulative survival rate was high when patients were receiving and complying with treatment. |
| Databáze: | OpenAIRE |
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