Prevalence of Body Iron Excess in the Metabolic Syndrome
| Autor: | Simonetta Friso, Francesca Pizzolo, Giovanna De Matteis, Oliviero Olivieri, Claudia Bozzini, Antonella Bassi, Roberto Corrocher, Ilaria Tenuti, Valentina Lotto, Domenico Girelli, Nicola Martinelli |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Iron Overload Waist Endocrinology Diabetes and Metabolism medicine.medical_treatment metabolic syndrome iron prevalency chemistry.chemical_compound Insulin resistance Reference Values Internal medicine Diabetes mellitus Internal Medicine medicine Humans Advanced and Specialized Nursing business.industry Cholesterol Insulin Middle Aged medicine.disease Obesity C-Reactive Protein Blood pressure Endocrinology chemistry Female Metabolic syndrome business |
| Zdroj: | Diabetes Care. 28:2061-2063 |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/diacare.28.8.2061 |
| Popis: | The metabolic syndrome, clinically defined by the Adult Treatment Panel III (ATPIII) (1), affects ∼25% of western adults (2). The metabolic syndrome is closely linked to insulin resistance and implies an increased cardiovascular risk (3,4). Accumulating evidence suggests a link between body iron excess and insulin metabolism (5). Studies have shown an association between serum ferritin and one or more metabolic syndrome feature (6–11). Moreover, a syndrome characterized by hepatic iron overload (HIO) associated with insulin resistance features (insulin resistance–associated HIO [IR-HIO]), unrelated to genetic hemochromatosis, has been described (12,13). IR-HIO currently represents the most frequent indication to venesection in referral care units for iron overload (14). Data on the other side of the phenomenon, namely the prevalence of a potentially relevant iron overload in subjects selected for having metabolic syndrome, are scanty. Within the registry of the Verona Heart Project (15), we identified metabolic syndrome subjects according to ATPIII because of three of more of the following: 1 ) fasting glucose ≥110 mg/dl or antidiabetes medication, 2 ) hypertension (blood pressure ≥135/85 mmHg or medication), 3 ) triglycerides ≥150 mg/dl, 4 ) HDL cholesterol |
| Databáze: | OpenAIRE |
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