Diagnostic Efficacy of Synthesized 2D Digital Breast Tomosynthesis in Multi-ethnic Malaysian Population

Autor:	Marlina Tanty Ramli, Kwan Hoong Ng, Caroline Judy Westerhout, Faizatul Izza Rozalli, N. Ab Mumin, Kartini Rahmat, Norlisah Ramli, Farhana Fadzli
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	0301 basic medicine Adult Breast imaging Population lcsh:Medicine Breast Neoplasms Sensitivity and Specificity Article 03 medical and health sciences 0302 clinical medicine Malaysian population Medicine Humans Breast density education lcsh:Science Early Detection of Cancer Aged education.field_of_study Multidisciplinary business.industry lcsh:R Malaysia Digital Breast Tomosynthesis Gold standard (test) Middle Aged Full field digital mammography Tomosynthesis 030104 developmental biology Radiographic Image Interpretation Computer-Assisted Female lcsh:Q business Nuclear medicine 030217 neurology & neurosurgery Mammography
Zdroj:	Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019) Scientific Reports
ISSN:	2045-2322
Popis:	Synthesized 2D images can be reconstructed from tomosynthesis images in breast imaging. This study aims to investigate the diagnostic efficacy of synthesized 2D images (C-View) in comparison to full field digital mammography (FFDM) when used with digital breast tomosynthesis (DBT) in multi-ethnic Malaysian population. FFDM and C-View images (n = 380) were independently evaluated by three readers through Breast Imaging Reporting and Data System (BI-RADS) categorisation, breast density and lesion characterisation. Statistical analysis was done comparing sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of C-View + DBT with FFDM + DBT as standard of reference. Very good interreader agreement in BI-RADS category and density assessment between C-View + DBT and FFDM + DBT, with high sensitivity, specificity, PPV and NPV of C-View + DBT when compared with FFDM + DBT. There was comparable PPV between C-View + DBT and FFDM + DBT, with histopathology as gold standard. High level of interreader agreement in BI-RADS category and density assessment for FFDM + DBT and C-View + DBT. There was good agreement between FFDM + DBT and C-View + DBT in mass characterization, and almost perfect agreement in calcification and asymmetric density. 52.2% lower radiation dose incurred when using C-View + DBT. Hence, synthesized 2D images are comparable to FFDM with reduction in radiation dose within the limits of Malaysian multi-ethnic population.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b24ab60cea0c35a12a4bdb159dd3ea0d http://link.springer.com/article/10.1038/s41598-018-37451-4 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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