Metabolic complications of hepatitis C virus infection
| Autor: | Sherouk Fouda, Ashik Sainu, Joseph M Pappachan, Rahul B. Chaudhari |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Liver Cirrhosis
Cirrhosis Hepatitis C virus Hepacivirus Review Disease medicine.disease_cause 03 medical and health sciences Liver disease Diabetes mellitus 0302 clinical medicine Fatty liver medicine Humans business.industry Liver Neoplasms Gastroenterology Insulin resistance General Medicine Hepatitis C Hepatitis C Chronic medicine.disease Metabolic syndrome Chronic hepatitis C infection Cardiovascular diseases 030220 oncology & carcinogenesis Hepatocellular carcinoma Immunology 030211 gastroenterology & hepatology business |
| Zdroj: | World Journal of Gastroenterology |
| ISSN: | 1007-9327 |
| DOI: | 10.3748/wjg.v27.i13.1267 |
| Popis: | Hepatitis C virus (HCV) infection is a systemic disease that is implicated in multiple extrahepatic organ dysfunction contributing to its protean manifestations. HCV is associated with diverse extrahepatic disorders including atherosclerosis, glucose and lipid metabolic disturbances, alterations in the iron metabolic pathways, and lymphoproliferative diseases over and above the traditional liver manifestations of cirrhosis and hepatocellular carcinoma. The orchestration between HCV major proteins and the liver-muscle-adipose axis, poses a major burden on the global health of human body organs, if not adequately addressed. The close and inseparable associations between chronic HCV infection, metabolic disease, and cardiovascular disorders are specifically important considering the increasing prevalence of obesity and metabolic syndrome, and their economic burden to patients, the healthcare systems, and society. Cellular and molecular mechanisms governing the interplay of these organs and tissues in health and disease are therefore of significant interest. The coexistence of metabolic disorders and chronic hepatitis C infection also enhances the progression to liver fibrosis and hepatocellular carcinoma. The presence of metabolic disorders is believed to influence the chronicity and virulence of HCV leading to liver disease progression. This comprehensive review highlights current knowledge on the metabolic manifestations of hepatitis C and the potential pathways in which these metabolic changes can influence the natural history of the disease. |
| Databáze: | OpenAIRE |
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